FORMULATION AND EVALUATION OF ORAL DISINTEGRATING TABLET OF TELMISARTAN USING SUPERDISINTEGRANTS

Registration ID: IJNRD_225721

Published ID: IJNRD2407495

DOI: Click Here to Get

Bishnu Upreti

Telmisartan, Croscarmellose sodium, Crospovidone, Sodium Starch Glycolate, Sodium Bicarbonate, Oral disintegrating tablets.

This research aims to develop and assess Oral Disintegrating Tablets (ODTs) of Telmisartan using various superdisintegrants. The superdisintegrants used in this study—crospovidone, sodium starch glycolate, and croscarmellose sodium—exhibit versatile properties that enhance the formulation of ODTs with Telmisartan, an antihypertensive drug classified under Angiotensin Receptor II (Type-AT1) Antagonists. Telmisartan, a poorly soluble drug (BCS Class II), has its absorption limited by its dissolution rate, with oral bioavailability ranging from 42% to 58%. This research aims to improve the dissolution properties of Telmisartan by formulating ODTs with these superdisintegrants. Various batches of ODTs were prepared using different concentrations of croscarmellose sodium, crospovidone, sodium starch glycolate, and sodium bicarbonate as a disintegrant through wet granulation. Sweeteners were added to enhance the palatability of the tablets. The tablets underwent evaluation for pre-compression parameters (bulk density, compressibility, angle of repose) and post-compression parameters (hardness, weight variation, friability, disintegration time, and in-vitro dissolution profiles). Among the formulations, the one containing 5.38% crospovidone, 1.5% sodium starch glycolate, 6.9% croscarmellose sodium, and 7.7% sodium bicarbonate emerged as the best, exhibiting a 97.12% drug release within 12 minutes and a disintegration time of 17 seconds. This formulation (F4) demonstrated superior results across all evaluation criteria

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Bishnu Upreti (July-2024). FORMULATION AND EVALUATION OF ORAL DISINTEGRATING TABLET OF TELMISARTAN USING SUPERDISINTEGRANTS. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(7), f945-f956. https://ijnrd.org/papers/IJNRD2407495.pdf

Volume 9 Issue 7, July-2024

Pages : f945-f956

Paper Reg. ID: IJNRD_225721

Published Paper Id: IJNRD2407495

Downloads: 000121987

Research Area: Engineering

Country: -, -, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2407495.pdf

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Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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