FORMULATION AND EVALUTION OF MUCOADHESIVE NASAL FILMS OF QUETIAPINE FUMARATE

Registration ID: IJNRD_225796

Published ID: IJNRD2407429

DOI: Click Here to Get

Lalam Ramanamma , V.John Babu , V.Uma maheswari , M.karthik varma , V.Alekya

schizophrenia, Quetiapine fumarate, mucoadhesion, bioavailability, patient compliance, nasal films

Nasal drug delivery has acquired attention as a hopeful alternative to oral administration due to its potential for rapid onset of action and avoidance of hepatic first-pass metabolism. This study presents a novel formulation of quetiapine fumarate as nasal films, aiming to improve drug bioavailability and patient compliance. The nasal films were prepared using a combination of hydroxypropyl methylcellulose (HPMC) and poly vinyl pyrrolidine (PVP) as polymers, with varying concentrations of quetiapine fumarate. The films were characterized for their physicochemical properties, including thickness, folding endurance, drug content, and in vitro drug release profile. Furthermore, the nasal films were evaluated for their mucoadhesive properties and ex vivo permeation across porcine nasal mucosa. The results demonstrated that the nasal films exhibited good mechanical strength, uniform drug content, and sustained drug release characteristics. The mucoadhesive properties of the films ensured prolonged contact with the nasal mucosa, leading to enhanced drug permeation. Overall, the formulation of quetiapine fumarate as nasal films presents a promising approach for improving drug delivery efficiency and patient adherence in the treatment of schizophrenia.

Published Paper   E-Certificate

Lalam Ramanamma, V.John Babu , V.Uma maheswari , M.karthik varma, & V.Alekya (July-2024). FORMULATION AND EVALUTION OF MUCOADHESIVE NASAL FILMS OF QUETIAPINE FUMARATE . INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(7), f294-f306. https://ijnrd.org/papers/IJNRD2407429.pdf

Volume 9 Issue 7, July-2024

Pages : f294-f306

Paper Reg. ID: IJNRD_225796

Published Paper Id: IJNRD2407429

Downloads: 000121992

Research Area: Pharmacy

Country: visakhapatnam, Andhra pradesh, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2407429.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2407429

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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