Paper Title
FORMULATION AND EVALUTION OF MUCOADHESIVE NASAL FILMS OF QUETIAPINE FUMARATE
Article Identifiers
: Authors
Keywords
schizophrenia, Quetiapine fumarate, mucoadhesion, bioavailability, patient compliance, nasal films
Abstract
Nasal drug delivery has acquired attention as a hopeful alternative to oral administration due to its potential for rapid onset of action and avoidance of hepatic first-pass metabolism. This study presents a novel formulation of quetiapine fumarate as nasal films, aiming to improve drug bioavailability and patient compliance. The nasal films were prepared using a combination of hydroxypropyl methylcellulose (HPMC) and poly vinyl pyrrolidine (PVP) as polymers, with varying concentrations of quetiapine fumarate. The films were characterized for their physicochemical properties, including thickness, folding endurance, drug content, and in vitro drug release profile. Furthermore, the nasal films were evaluated for their mucoadhesive properties and ex vivo permeation across porcine nasal mucosa. The results demonstrated that the nasal films exhibited good mechanical strength, uniform drug content, and sustained drug release characteristics. The mucoadhesive properties of the films ensured prolonged contact with the nasal mucosa, leading to enhanced drug permeation. Overall, the formulation of quetiapine fumarate as nasal films presents a promising approach for improving drug delivery efficiency and patient adherence in the treatment of schizophrenia.
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How To Cite (APA)
Lalam Ramanamma, V.John Babu , V.Uma maheswari , M.karthik varma, & V.Alekya (July-2024). FORMULATION AND EVALUTION OF MUCOADHESIVE NASAL FILMS OF QUETIAPINE FUMARATE . INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(7), f294-f306. https://ijnrd.org/papers/IJNRD2407429.pdf
Issue
Volume 9 Issue 7, July-2024
Pages : f294-f306
Other Publication Details
Paper Reg. ID: IJNRD_225796
Published Paper Id: IJNRD2407429
Downloads: 000122028
Research Area: Pharmacy
Author Type: Indian Author
Country: visakhapatnam, Andhra pradesh, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2407429.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2407429
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