HEPATOPROTECTIVE ACTIVITY OF BOERHAAVIA DIFFUSA ROOTS EXTRACTS AGAINST METHOTREXATE INDUCED HEPATOTOXICITY

Registration ID: IJNRD_225375

Published ID: IJNRD2407287

DOI: Click Here to Get

Diksha Sharma , Sanober Parveen

Boerhviaa Diffusa, Methotrexate, Hepatoprotectives, Hepatotoxicity

This study has been undertaken to investigate the hepatic activity of ethanolic roots extract of against Methotrexate induced hepatotoxicity in albino Wistar rats (150-200 gm) . The roots of which source of bioactive compounds including polyphenol, terpenes alkaloids glycoside steroids and various health benefits including antioxidants, anti-microbials agents, anti-cancer agents anti-convulsion agents’ radio protective compounds. extraction was carried by Soxhlet apparatus of Boerhaavia diffusa roots was performed by using ethanol solvents. Experimental designed was randomly divided in five groups contains Normal control, Disease control, standard control, test 1(LD), and test 2 (HD). The treatment was given for 14th days on 15th days the blood was collected via retro orbital route and kept for 30 minutes at 25 ͦC for clotting following by centrifugation at 2000 rpm for 15 minutes. sera will be collected and performed biochemicals analyses (SGOT, SGPT ALP, TB). The animals were sacrificed after anesthesia. The liver was cut into two parts and one part of tissue excused for homogenate that were used for biochemical parameters (Malondialdehyde, Superoxide dismutase, Glutathione, Catalase) and other part of was used for histopathological studies. Acute toxicity study does not show any mortality and behavial changes 2000 mg/kg extracts. Therefore, pharmacological shows 1/10 the of maximum tolerated dose was selected lower dose 200mg/kg and just double of lower dose was considered the higher dose (400mg/kg). Animal treated with ethanolic extracts of Boerhaavia diffusa roots significantly altered the disease control groups. The result of this shows that the hepatoprotective activity of ethanolic extracts of Boerhaavia diffusa roots. Conclusion of that to be finding of shows scavenges free radicals

Published Paper   E-Certificate

Diksha Sharma & Sanober Parveen (July-2024). HEPATOPROTECTIVE ACTIVITY OF BOERHAAVIA DIFFUSA ROOTS EXTRACTS AGAINST METHOTREXATE INDUCED HEPATOTOXICITY . INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(7), c912-c923. https://ijnrd.org/papers/IJNRD2407287.pdf

Volume 9 Issue 7, July-2024

Pages : c912-c923

Paper Reg. ID: IJNRD_225375

Published Paper Id: IJNRD2407287

Downloads: 000121980

Research Area: Pharmacy

Country: Gorakhpur, Uttar Pradesh, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2407287.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2407287

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJNRD (IJ Publication) Janvi Wave | IJNRD.ORG | IJNRD.COM | IJPUB.ORG

This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition

Call For Paper - Volume 10 | Issue 10 | October 2025

IJNRD is a Scholarly Open Access, Peer-reviewed, and Refereed Journal with a High Impact Factor of 8.76 (calculated by Google Scholar & Semantic Scholar | AI-Powered Research Tool). It is a Multidisciplinary, Monthly, Low-Cost Journal that follows UGC CARE 2025 Peer-Reviewed Journal Policy norms, Scopus journal standards, and Transparent Peer Review practices to ensure quality and credibility. IJNRD provides indexing in all major databases & metadata repositories, a citation generator, and Digital Object Identifier (DOI) for every published article with full open-access visibility.

The INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (IJNRD) aims to advance applied, theoretical, and experimental research across diverse fields. Its goal is to promote global scientific information exchange among researchers, developers, engineers, academicians, and practitioners. IJNRD serves as a platform where educators and professionals can share research evidence, models of best practice, and innovative ideas, contributing to academic growth and industry relevance.

Indexing Coverage includes Google Scholar, SSRN, ResearcherID-Publons, Semantic Scholar (AI-Powered Research Tool), Microsoft Academic, Academia.edu, arXiv.org, ResearchGate, CiteSeerX, ResearcherID (Thomson Reuters), Mendeley, DocStoc, ISSUU, Scribd, and many more recognized academic repositories.

How to submit the paper?

By Our website

Click Here to Submit Paper Online

By Mail

Send your paper to editor@ijnrd.org

Important Dates for Current issue

Paper Submission Open For: October 2025

Current Issue: Volume 10 | Issue 10 | October 2025

Impact Factor: 8.76

Last Date for Paper Submission: Till 31-Oct-2025

Notification of Review Result: Within 1-2 Days after Submitting paper.

Publication of Paper: Within 01-02 Days after Submititng documents.

Frequency: Monthly (12 issue Annually).

Journal Type: IJNRD is an International Peer-reviewed, Refereed, and Open Access Journal with Transparent Peer Review as per the new UGC CARE 2025 guidelines, offering low-cost multidisciplinary publication with Crossref DOI and global indexing.

Subject Category: Research Area

Call for Paper: More Details