HEPATOPROTECTIVE ACTIVITY OF BOERHAAVIA DIFFUSA ROOTS EXTRACTS AGAINST METHOTREXATE INDUCED HEPATOTOXICITY

HEPATOPROTECTIVE ACTIVITY OF BOERHAAVIA DIFFUSA ROOTS EXTRACTS AGAINST METHOTREXATE INDUCED HEPATOTOXICITY

Registration ID: IJNRD_225375

Published ID: IJNRD2407287

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Diksha Sharma , Sanober Parveen

Boerhviaa Diffusa, Methotrexate, Hepatoprotectives, Hepatotoxicity

This study has been undertaken to investigate the hepatic activity of ethanolic roots extract of against Methotrexate induced hepatotoxicity in albino Wistar rats (150-200 gm) . The roots of which source of bioactive compounds including polyphenol, terpenes alkaloids glycoside steroids and various health benefits including antioxidants, anti-microbials agents, anti-cancer agents anti-convulsion agents’ radio protective compounds. extraction was carried by Soxhlet apparatus of Boerhaavia diffusa roots was performed by using ethanol solvents. Experimental designed was randomly divided in five groups contains Normal control, Disease control, standard control, test 1(LD), and test 2 (HD). The treatment was given for 14th days on 15th days the blood was collected via retro orbital route and kept for 30 minutes at 25 ͦC for clotting following by centrifugation at 2000 rpm for 15 minutes. sera will be collected and performed biochemicals analyses (SGOT, SGPT ALP, TB). The animals were sacrificed after anesthesia. The liver was cut into two parts and one part of tissue excused for homogenate that were used for biochemical parameters (Malondialdehyde, Superoxide dismutase, Glutathione, Catalase) and other part of was used for histopathological studies. Acute toxicity study does not show any mortality and behavial changes 2000 mg/kg extracts. Therefore, pharmacological shows 1/10 the of maximum tolerated dose was selected lower dose 200mg/kg and just double of lower dose was considered the higher dose (400mg/kg). Animal treated with ethanolic extracts of Boerhaavia diffusa roots significantly altered the disease control groups. The result of this shows that the hepatoprotective activity of ethanolic extracts of Boerhaavia diffusa roots. Conclusion of that to be finding of shows scavenges free radicals

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"HEPATOPROTECTIVE ACTIVITY OF BOERHAAVIA DIFFUSA ROOTS EXTRACTS AGAINST METHOTREXATE INDUCED HEPATOTOXICITY ", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.9, Issue 7, page no.c912-c923, July-2024, Available :https://ijnrd.org/papers/IJNRD2407287.pdf

Volume 9 Issue 7, July-2024

Pages : c912-c923

Paper Reg. ID: IJNRD_225375

Published Paper Id: IJNRD2407287

Downloads: 000121142

Research Area: Pharmacy

Country: Gorakhpur, Uttar Pradesh, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2407287.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2407287

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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