STUDY OF CLINICAL PROFILE OF FEBRILE CHILDREN PRESENTING WITH THROMBOCYTOPENIA

Registration ID: IJNRD_225266

Published ID: IJNRD2407243

DOI: http://doi.one/10.1729/Journal.40596

DR.ATIULLAH KHAN , DR.PRADEEP KUMAR RANABIJULI , DR.ASHISH SATISEVAK , DR.RAKESH AGARWAL , DR. AYESHA KHAN

Dengue, Malaria, Petechia, Purpura, Enteric, Fever ,Sepsis

INTRODUCTION Patients with acute febrile illnesses in a tropical country like India usually have an infectious etiology and may have associated thrombocytopenia. Infections like malaria, dengue, leptospirosis, and typhoid are some of the common causes of fever with thrombocytopenia. A well-organized systematic approach that is carried out with an awareness of the causes of fever with thrombocytopenia can shorten the number of investigations and bring out the diagnosis. Thrombocytopenia being a prognostic factor in fever can predict the cause and thus helps in early diagnosis and treatment of the same, preventing further fatal outcomes such as intracranial bleeding, hemorrhage into vital organs, shock, and death. Hence analyzing the clinical profile of fever with thrombocytopenia, as early diagnosis and timely intervention would prevent adverse outcomes and save lives. MATERIAL AND METHODS Sample Size: 150 cases were selected aged less than 18 years with fever and thrombocytopenia. Inclusion criteria: Patients of both sexes aged >1 month to < 18 years. Patients admitted with fever and found to have thrombocytopenia(platelet count <1.5 lakhs). RESULTS The maximum number of cases was found to be in the age group of 5-10 years, with a male: female ratio of 56%:44%. Infection is the commonest cause of fever with thrombocytopenia. Acute undifferentiated febrile illnesses were the commonest cause when a definitive diagnosis could not be made. Dengue formed the second largest group in diagnosed cases. Malaria was the third largest with vivax being the commonest species. The common range of platelet count at the time of admission was above 50,000/uL. Among cases with bleeding manifestations, petechia/purpura was the most common presentation. Most who showed bleeding manifestations were found to be dengue cases. Majority of leucocytosis was seen in acute febrile illnesses followed by dengue, malaria, enteric fever, and sepsis. Majority of leucopenia was found in dengue followed by malaria cases. Hypotension was the most common complication found in the study. Among mortalities, dengue was the most common etiology followed by septicemia. Deaths in the study were due to multiorgan dysfunction. CONCLUSION Febrile thrombocytopenia is an important clinical condition commonly caused by infections. Thrombocytopenia has an inverse relation to mortality and morbidity in various febrile illnesses. Serial monitoring of platelet counts has prognostic value. Mortality in febrile thrombocytopenia is not directly associated with the degree of thrombocytopenia but with concomitant involvement of other organs leading to multiorgan dysfunction. Hence, early diagnosis and treatment of febrile illness with thrombocytopenia will prevent complications like renal failure, hepatic dysfunction, acute respiratory distress syndrome, and severe bleeding.

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DR.ATIULLAH KHAN, DR.PRADEEP KUMAR RANABIJULI, DR.ASHISH SATISEVAK, DR.RAKESH AGARWAL , & DR. AYESHA KHAN (July-2024). STUDY OF CLINICAL PROFILE OF FEBRILE CHILDREN PRESENTING WITH THROMBOCYTOPENIA. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(7), c400-c404. http://doi.one/10.1729/Journal.40596

Volume 9 Issue 7, July-2024

Pages : c400-c404

Paper Reg. ID: IJNRD_225266

Published Paper Id: IJNRD2407243

Downloads: 000121991

Research Area: Medical Science

Country: MUMBAI SUBURBAN , MAHARASHTRA, India

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Crossref DOI: http://doi.one/10.1729/Journal.40596

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

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