Paper Title
VEGF Expression in Esophageal cancer with Associated Demographic and Pathological Features as Seen in the Department of Pathology, Makerere University
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Registration ID: IJNRD_224980
Published ID: IJNRD2407211
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Abstract
Esophageal squamous cell carcinoma is the most prevalent type of esophageal cancer worldwide. Esophageal adenocarcinoma is the most common type in developed countries. Vascular Endothelial Growth Factor (VEGF), a signal protein produced by cells that stimulates the process of angiogenesis has been shown to be expressed in esophageal carcinoma tumor tissue. The study was a cross sectional laboratory-based study. Formalin fixed and paraffin embedded (FFPE) tissue blocks of 110 patients diagnosed with esophageal cancer at the department of Pathology. Data abstraction form forms were used to capture variables; that is age, sex, tumor histological subtype, grade and VEGF protein expression and then analysis was done using STATA version 14. For measures of association, 95% confidence interval was used and a p-value of less than 0.05 was considered statistically significant. The mean age of patients from which specimens had been collected was 59 years with a standard deviation of 11 years. Most of the patients were males, 71(64.6%). Majority of the specimens were of conventional squamous cell histological type, 101 (91.8%) and of moderately differentiated histological grade, 58 (52.7%). The prevalence of VEGF expression was 51.8% (57/110). There was no statistically significant association between VEGF expression and age, histological type and grade of esophageal carcinoma. There is a 51.8% of expression of VEGF in esophageal cancer in our study. Our study may help better patient management and improve knowledge gap of VEGF expression in esophageal cancer in Uganda.
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How To Cite (APA)
Juwairia Mohamed Ahmed, Kimwero Mohamed, & Phiona Bukirwra (July-2024). VEGF Expression in Esophageal cancer with Associated Demographic and Pathological Features as Seen in the Department of Pathology, Makerere University. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(7), c108-c115. https://ijnrd.org/papers/IJNRD2407211.pdf
Issue
Volume 9 Issue 7, July-2024
Pages : c108-c115
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Paper Reg. ID: IJNRD_224980
Published Paper Id: IJNRD2407211
Research Area: Medical Science
Author Type: Foreign Author
Country: kampala, Kampala , Uganda
Published Paper PDF: https://ijnrd.org/papers/IJNRD2407211.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2407211
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