Paper Title
NEUROPROTECTIVE EFFECT OF LITCHI CHINENSIS SONN IN HALOPERIDOL INDUCED NEURODEGENERATION IN RAT MODELS
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Authors
Vinjavarapu L. Anusha , Dr.v. Anitha kumari , Dr.B.Thangabalan , A.Vyshnavi , B. Venkata Lakshmi, Sk. Raquieb, E. Vinay Rakshan Kumar, M. Pawan kumar
Keywords
NEUROPROTECTIVE EFFECT OF LITCHI CHINENSIS SONN IN HALOPERIDOL INDUCED NEURODEGENERATION IN RAT MODELS
Abstract
Using a rat model of haloperidol-induced catalepsy, the antioxidant and anticataleptic properties of litchi chinensis Sonn's methanolic seed extract were examined by the measurement of several behavioral and biochemical parameters. Haloperidol (1 mg/kg, ip) was given to a female albino rat in order to cause catalepsy. All drug-treated groups showed a substantial decrease in cataleptic ratings when compared to the haloperidol-treated group; the group that received Nelumbo nuciferi (200 and 400 mg/kg body weight) saw the largest decrease. In the brain, biochemical markers such as dopamine (DA), reduced glutathione (GSH), catalase (CAT), thiobirbituric acid reactive substances (TBARS), and catalase and superoxide bismutise (SOD) were measured. When haloperidol was administered, the levels of SOD and catalase decreased and the production of TBARS and dopamine rose. This study found that in rats with haloperidol-induced catalepsy, therapy with Litchi chinensis Sonn restored the levels of TBARS, catalase, and SOD.
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How To Cite (APA)
Vinjavarapu L. Anusha, Dr.v. Anitha kumari , Dr.B.Thangabalan , A.Vyshnavi , & B. Venkata Lakshmi, Sk. Raquieb, E. Vinay Rakshan Kumar, M. Pawan kumar (July-2024). NEUROPROTECTIVE EFFECT OF LITCHI CHINENSIS SONN IN HALOPERIDOL INDUCED NEURODEGENERATION IN RAT MODELS. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(7), b853-b865. https://ijnrd.org/papers/IJNRD2407188.pdf
Issue
Volume 9 Issue 7, July-2024
Pages : b853-b865
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Paper Reg. ID: IJNRD_220653
Published Paper Id: IJNRD2407188
Downloads: 000121987
Research Area: Engineering
Country: -, -, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2407188.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2407188
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