Paper Title
Neurobehavioral and Neurochemical of Effect of Azadirachta Indica on Stress Induced Anxiety in Mice
Article Identifiers
Authors
Ms. Jyoti Rajput , Mr. Akash Sharma
Keywords
Azadirachta indica A. Juss, Synthetic drugs, Mice, Extract, Effect, Dose, Toxicity.
Abstract
Anxiety disorder is common mental disorders that share extreme or pathological anxiety as the primary disturbance in mood or emotional tone. Biochemical alteration are observed in anatomical centers, which are responsible for processing of emotions and are connected to ―stress‖ axis , which is strongly activated in response to threat or fear. The imbalances in the neurotransmitters like GABA, Serotonin, nor adrenaline, Dopamine etc mainly causes anxiety disorders. Synthetic drugs available for treatment of anxiety have various adverse effects including drowsiness, ataxia with benzodiazepines and insomnia, libido with selective serotonin reuptake inhibitors. Azadirachta indica A. Juss, common name Neem, Neem tree, Indian-lilac (Canada), Margosa, Nimtree and mMrgosier, family Maliacea, responsible for some of the already mentioned neem benefits, they are known to possess immunomodulatory, antiinflammatory, antihyperglycaemic, antiulcer, antimalarial, antifungal, antibacterial, antiviral, antioxidant, antimutagenic and anti-carcinogenic properties being one of the most active parts of the plant. Behavioral parameters are the primary evidence to confirm anxiety as well as anti-anxiety effect of treatments. All the parameters are based on pathophysilogy of anxiety because anxiety or fear is evaluated through stress or immobilization of animal like mice and rats. On the bases of behavioral parameters as well as biochemical estimation, study concludes that Azadirachta indica shows significant effect in plasma nitrates and other chemical messenger in anxiety at dose of 200mg/kg
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How To Cite (APA)
Ms. Jyoti Rajput & Mr. Akash Sharma (July-2024). Neurobehavioral and Neurochemical of Effect of Azadirachta Indica on Stress Induced Anxiety in Mice. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(7), b786-b792. https://ijnrd.org/papers/IJNRD2407182.pdf
Issue
Volume 9 Issue 7, July-2024
Pages : b786-b792
Other Publication Details
Paper Reg. ID: IJNRD_225085
Published Paper Id: IJNRD2407182
Downloads: 000121975
Research Area: Pharmacy
Country: Sagar, Madhya Pradesh, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2407182.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2407182
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