Paper Title
Development and In-vitro characterization of Eudragit RS100 coated alginate microspore of diclofenac sodium thermosensitive gel for ocular delivery
Article Identifiers
Registration ID: IJNRD_224203
Published ID: IJNRD2407175
: Click Here to Get
About Hard Copy and Transparent Peer Review Report
Authors
Keywords
Diclofenac sodium, painkiller, pharmaceutics,occular, alginateMicrosphere,eudragit rs100,in vitro.
Abstract
The paper provides a comprehensive overview of the motivations driving the current research endeavor, elucidating the specific objectives and expected outcomes.The aim of the current study is to prolong the residence time of diclofenac sodium using Eudragit-coated microspheres containing a thermosensitive gel. In the preformulation investigation, diclofenac sodium was white, crystalline, odorless, and tasteless. The melting point was 282.67°C±1.154 to 285.34°C±0.578. The UV spectrum of a 10µg/ml methanol solution showed absorption maxima at 283 nm. The linearity curve for diclofenac sodium in methanol (2-22µg/ml at 283 nm) was Y = 0.0393x+0.0202 with a regression coefficient of 0.999, indicating good linearity and accuracy. Solubility studies confirmed maximum solubility in methanol, followed by ethanol, with sparing solubility in water and simulated tear fluid. FTIR studies confirmed no interaction between diclofenac sodium and the excipients used. Diclofenac sodium-loaded microspheres were prepared by a water-in-oil emulsification method. Initial batches varied the amount of sodium alginate, followed by batches with different stirring speeds and times. Characterization of batch DAM8, containing 0.1%w/v diclofenac sodium, 5%w/v sodium alginate, stirred at 600 rpm for 120 minutes, showed spherical and discrete particles. Batch DAM8 had a percentage yield of 96.061±0.381%, drug entrapment of 99.528±0.903%, drug loading of 2.427±0.022%, and a particle size of 24.910±0.976µm. Coating with Eudragit RS 100 increased the residence time. The coated microsphere batch E2DAM8 had a percentage yield of 97.813±0.420%, drug entrapment of 98.706±0.467%, drug loading of 0.822±0.004%, and a particle size of 45.005±0.290µm. The coated microsphere formulation embedded in a thermosensitive gel carrier (poloxamer 407) showed pH 6.484±0.035, gelling time 12.334±1.527sec, and drug content 99.101±0.640%. The in-vitro drug release profile showed 96.768±0.510% release in 12 hours, compared to 99.059±0.180% in 2 hours for the aqueous solution. The Korsmeyer–Peppas model best described the release kinetics with a regression coefficient higher than 0.944.
Downloads
How To Cite (APA)
M.Aatif & Mrs.Monika bansal (July-2024). Development and In-vitro characterization of Eudragit RS100 coated alginate microspore of diclofenac sodium thermosensitive gel for ocular delivery. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(7), b734-b739. https://ijnrd.org/papers/IJNRD2407175.pdf
Issue
Volume 9 Issue 7, July-2024
Pages : b734-b739
Other Publication Details
Paper Reg. ID: IJNRD_224203
Published Paper Id: IJNRD2407175
Research Area: Pharmacy
Author Type: Indian Author
Country: Malerkotla, Punjab, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2407175.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2407175
About Publisher
Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)
UGC CARE JOURNAL PUBLICATION | ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016
An International UGC CARE JOURNAL PUBLICATION, Low Cost, Scholarly Open Access, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJNRD (IJ Publication) Janvi Wave | IJNRD.ORG | IJNRD.COM | IJPUB.ORG
Copyright & License
© 2026 - Authors hold the copyright of this article. This work is licensed under a Creative Commons Attribution 4.0 International License. and The Open Definition.
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (CC BY 4.0).
🛡️ Disclaimer: The content, data, and findings in this article are based on the authors’ research and have been peer-reviewed for academic purposes only. Readers are advised to verify all information before practical or commercial use.
The journal and its editorial board are not liable for any errors, losses, or consequences arising from its use.
Publication Timeline
Article Preview: View Full Paper
Call For Paper
IJNRD is a Scholarly Open Access, Peer-Reviewed, Refereed, and UGC CARE Journal Publication with a High Impact Factor of 8.76 (calculated by Google Scholar & Semantic Scholar | AI-Powered Research Tool). It is a Multidisciplinary, Monthly, Low-Cost, and Transparent Peer Review Journal Publication that adheres to the New UGC CARE Transparent Peer-Reviewed Journal Policy and aligns with Scopus Journal Publication standards to ensure the highest level of research quality and credibility.
IJNRD offers comprehensive Journal Publication Services including indexing in all major databases and metadata repositories, Digital Object Identifier (Crossref DOI) assignment for each published article with additional fees, citation generation tools, and full Open Access visibility to enhance global research reach and citation impact.
The INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (IJNRD) aims to advance applied, theoretical, and experimental research across diverse academic and professional fields. The journal promotes global knowledge exchange among researchers, developers, academicians, engineers, and practitioners, serving as a trusted platform for innovative, peer-reviewed journal publication and scientific collaboration.
Indexing Coverage: Google Scholar, SSRN, ResearcherID-Publons, Semantic Scholar (AI-Powered Research Tool), Microsoft Academic, Academia.edu, arXiv.org, ResearchGate, CiteSeerX, ResearcherID (Thomson Reuters), Mendeley, DocStoc, ISSUU, Scribd, and many other recognized academic repositories.
Transparent Peer Review Journal Publication: IJNRD operates a strict double-blind peer review system managed by 3000+ expert reviewers, ensuring ethical, unbiased, and high-quality review for every research paper.
For Indian Authors : Get a transparent peer review report from Scholar9.com for just ₹1000. View Sample Report
For Foreign Authors : A detailed peer review report is available through Scholar9.com for $20 USD. View Sample Report
Transparent Peer Review Journal Publication
⭐ Transparent Peer Review | 🕵️♂️ Double-Blind | 👨🏫 3000+ Expert Reviewers | 🇮🇳 Report for India Author ₹1000 | 🌐 Report for Foreign Author $20 | 📄 Sample Reports on Scholar9.com | 🌍 High Credibility | ⚖️ Ethical & Unbiased Evaluation
How to submit the paper?
By Our website
Click Here to Submit Paper Online
Recently, the UGC discontinued the UGC-CARE Journal List and introduced new parameters that allow publication in Transparent Peer-Reviewed (Refereed) Journals. IJNRD is Transparent Peer Review Journal Valid As per New UGC Notification.
You can now publish your research paper in IJNRD.ORG. IJNRD is a Transparent Peer-Reviewed Open Access (Refereed Journal), UGC and UGC CARE Approved, Crossref DOI, Multidisciplinary, Impact Factor calculate by Google Scholar. As an International, open-access, and online journal, Publishing with us ensures wider reach, academic credibility, and enhanced recognition for your work.
For more details, refer to the official notice: UGC Public Notice
⭐ Low Cost ₹1570 | 📚 UGC CARE Approved | 🔍 Peer-Reviewed | 🌐 Open Access | 🔗 Crossref DOI & Global Indexing | 📊 Google Scholar Impact Factor | 🧪 Multidisciplinary
Submit Paper Online Call for Paper About IJNRD UGC CARE Approval
Important Dates for Current issue
Paper Submission Open For: February 2026
Current Issue: Volume 11 | Issue 2 | February 2026
Impact Factor: 8.76
Last Date for Paper Submission: Till 28-Feb-2026
Notification of Review Result: Transparent peer review process - your paper is evaluated by experts, and you receive acceptance or rejection updates via email and SMS.
Publication of Paper: Once all documents are submitted, your paper is published without delay, and you can instantly download your certificate and confirmation letter online.
Frequency: Monthly (12 issue Annually).
Journal Type: IJNRD is an international open-access journal offering Low Cost Journal Publication, transparent Peer Review Journal Publication, Crossref DOI, and multidisciplinary research visibility under UGC CARE Approved Journal Publication.
Subject Category: Research Area
Approval, Licenses and Indexing: More Details
Call For Paper - Volume 11 | Issue 2 | February 2026
IJNRD.org offers low-cost journal publication starting at ₹1570 with UGC CARE Approved, refereed, peer-reviewed, open-access publishing. This multidisciplinary monthly journal, available in both online and print formats, features a strong Google Scholar-based impact factor of 8.76, Transparent Peer Review, CrossRef DOI, global indexing, fast publication, and complete metadata for maximum research visibility and citation impact across multidisciplinary domains.
Volume 11 | Issue 2 | February 2026 | IJNRD Transparent Peer Review Certificate | Submit Paper Online
⭐ UGC CARE Approved Refereed Journal | 🔍 Transparent Peer Review | 🌐 Open Access Publishing | 💰 Low-Cost ₹1570 | 🔗 CrossRef DOI & Global Indexing | 📊 Google Scholar Impact Factor 8.76 | 🧪 Multidisciplinary | Online & Print
Submit Paper Online
