Paper Title
Development and In-vitro characterization of Eudragit RS100 coated alginate microspore of diclofenac sodium thermosensitive gel for ocular delivery
Article Identifiers
Authors
M.Aatif , Mrs.Monika bansal
Keywords
Diclofenac sodium, painkiller, pharmaceutics,occular, alginateMicrosphere,eudragit rs100,in vitro.
Abstract
The paper provides a comprehensive overview of the motivations driving the current research endeavor, elucidating the specific objectives and expected outcomes.The aim of the current study is to prolong the residence time of diclofenac sodium using Eudragit-coated microspheres containing a thermosensitive gel. In the preformulation investigation, diclofenac sodium was white, crystalline, odorless, and tasteless. The melting point was 282.67°C±1.154 to 285.34°C±0.578. The UV spectrum of a 10µg/ml methanol solution showed absorption maxima at 283 nm. The linearity curve for diclofenac sodium in methanol (2-22µg/ml at 283 nm) was Y = 0.0393x+0.0202 with a regression coefficient of 0.999, indicating good linearity and accuracy. Solubility studies confirmed maximum solubility in methanol, followed by ethanol, with sparing solubility in water and simulated tear fluid. FTIR studies confirmed no interaction between diclofenac sodium and the excipients used. Diclofenac sodium-loaded microspheres were prepared by a water-in-oil emulsification method. Initial batches varied the amount of sodium alginate, followed by batches with different stirring speeds and times. Characterization of batch DAM8, containing 0.1%w/v diclofenac sodium, 5%w/v sodium alginate, stirred at 600 rpm for 120 minutes, showed spherical and discrete particles. Batch DAM8 had a percentage yield of 96.061±0.381%, drug entrapment of 99.528±0.903%, drug loading of 2.427±0.022%, and a particle size of 24.910±0.976µm. Coating with Eudragit RS 100 increased the residence time. The coated microsphere batch E2DAM8 had a percentage yield of 97.813±0.420%, drug entrapment of 98.706±0.467%, drug loading of 0.822±0.004%, and a particle size of 45.005±0.290µm. The coated microsphere formulation embedded in a thermosensitive gel carrier (poloxamer 407) showed pH 6.484±0.035, gelling time 12.334±1.527sec, and drug content 99.101±0.640%. The in-vitro drug release profile showed 96.768±0.510% release in 12 hours, compared to 99.059±0.180% in 2 hours for the aqueous solution. The Korsmeyer–Peppas model best described the release kinetics with a regression coefficient higher than 0.944.
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How To Cite (APA)
M.Aatif & Mrs.Monika bansal (July-2024). Development and In-vitro characterization of Eudragit RS100 coated alginate microspore of diclofenac sodium thermosensitive gel for ocular delivery. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(7), b734-b739. https://ijnrd.org/papers/IJNRD2407175.pdf
Issue
Volume 9 Issue 7, July-2024
Pages : b734-b739
Other Publication Details
Paper Reg. ID: IJNRD_224203
Published Paper Id: IJNRD2407175
Downloads: 000122005
Research Area: Pharmacy
Country: Malerkotla, Punjab, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2407175.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2407175
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Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)
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