Paper Title
DEVELOPMENT AND EVALUATION OF MUPIROCIN INVASOMES FOR ANTIBACTERIAL ACTIVITY
Article Identifiers
Authors
B.kamaleshwari , G.kaviya , R.Vignesh , M.Kovartthanan
Keywords
Mupirocin, invasomes, terpenes, topical delivery, antibacterial
Abstract
Mupirocin invasomes, incorporating soy lecithin and various terpenes (eugenol, citral, and D-limonene), were prepared using a mechanical dispersion method. Terpene concentrations influenced particle size, with citral containing invasomes (F5) exhibiting the smallest size (92nm to 1250nm).The polydispersibility index indicated uniform particle size distribution (0.136-0.624), confirming homogeneous preparation. Increasing terpene concentration correlated with larger particle sizes. Zeta potential values ranged from -62.2mV to +8.4mV, favoring drug penetration and formulation stability. Formulation F5 demonstrated the highest entrapment efficiency (83%) and drug content (90%), suggesting effective Mupirocin encapsulation. In-vitro release kinetics showed percentages between 62% and 86% at 30 hours, following first-order kinetics. Anti-bacterial activity against Staphylococcus aureus varied across formulations (10mm to 20mm zones of inhibition), with F2 exhibiting the highest and F10 the lowest inhibition zones. Stability studies indicated consistent performance of F5 over three months. Overall, Mupirocin invasomes, especially F5, present a promising strategy for the topical treatment of bacterial skin infections, offering sustained release, enhanced penetration, and antibacterial efficacy.
Downloads
How To Cite (APA)
B.kamaleshwari, G.kaviya, R.Vignesh, & M.Kovartthanan (July-2024). DEVELOPMENT AND EVALUATION OF MUPIROCIN INVASOMES FOR ANTIBACTERIAL ACTIVITY. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(7), b473-b494. https://ijnrd.org/papers/IJNRD2407148.pdf
Issue
Volume 9 Issue 7, July-2024
Pages : b473-b494
Other Publication Details
Paper Reg. ID: IJNRD_224723
Published Paper Id: IJNRD2407148
Downloads: 000121980
Research Area: Pharmacy
Country: Coimbatore, Tamil nadu, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2407148.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2407148
About Publisher
Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)
ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJNRD (IJ Publication) Janvi Wave | IJNRD.ORG | IJNRD.COM | IJPUB.ORG
Licence
This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition
Publication Timeline
Article Preview: View Full Paper
Call For Paper
IJNRD is a Scholarly Open Access, Peer-reviewed, and Refereed Journal with a High Impact Factor of 8.76 (calculated by Google Scholar & Semantic Scholar | AI-Powered Research Tool). It is a Multidisciplinary, Monthly, Low-Cost Journal that follows UGC CARE 2025 Peer-Reviewed Journal Policy norms, Scopus journal standards, and Transparent Peer Review practices to ensure quality and credibility. IJNRD provides indexing in all major databases & metadata repositories, a citation generator, and Digital Object Identifier (DOI) for every published article with full open-access visibility.
The INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (IJNRD) aims to advance applied, theoretical, and experimental research across diverse fields. Its goal is to promote global scientific information exchange among researchers, developers, engineers, academicians, and practitioners. IJNRD serves as a platform where educators and professionals can share research evidence, models of best practice, and innovative ideas, contributing to academic growth and industry relevance.
Indexing Coverage includes Google Scholar, SSRN, ResearcherID-Publons, Semantic Scholar (AI-Powered Research Tool), Microsoft Academic, Academia.edu, arXiv.org, ResearchGate, CiteSeerX, ResearcherID (Thomson Reuters), Mendeley, DocStoc, ISSUU, Scribd, and many more recognized academic repositories.
How to submit the paper?
By Our website
Click Here to Submit Paper Online
Important Dates for Current issue
Paper Submission Open For: October 2025
Current Issue: Volume 10 | Issue 10 | October 2025
Impact Factor: 8.76
Last Date for Paper Submission: Till 31-Oct-2025
Notification of Review Result: Within 1-2 Days after Submitting paper.
Publication of Paper: Within 01-02 Days after Submititng documents.
Frequency: Monthly (12 issue Annually).
Journal Type: IJNRD is an International Peer-reviewed, Refereed, and Open Access Journal with Transparent Peer Review as per the new UGC CARE 2025 guidelines, offering low-cost multidisciplinary publication with Crossref DOI and global indexing.
Subject Category: Research Area
Call for Paper: More Details
