Momordica charantia, a Nutraceutical Approach for Inflammatory Related Disease(Cancer)

Registration ID: IJNRD_224731

Published ID: IJNRD2407129

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JANVI SANTOSH NADEKAR , Mrs. Bhagyashree koli chaudhary

Momordica charantia, commonly called bitter gourd, is a plant belonging to the Cucurbitaceae family and has been known for centuries for its medicinal and nutritional properties. Due to the presence of many bioactive compounds, some of which have strong biological effects, this plant is used in folk medicine all over the world, primarily for diabetes, but also for other diseases related to cancer and inflammation.It is used to treat a variety of medical conditions, including: M. charantia extract has been widely proven to help lower blood sugar levels in patients with type 2 diabetes.Most of the existing research on M. Charantia's bioactive compounds have only been tested in cell lines and animal models. Therefore, the actual effects of bitter melon on human health are not fully established, and systematic clinical trials are needed to establish the efficacy and safety of bitter melon for patients.Additionally, both in vitro and in vivo studies have shown that bitter melon can cause toxic or harmful effects under various conditions. The purpose of this review is to provide an overview of the anti-inflammatory and antitumor properties of bitter melon and discuss its pharmacological activities and possible side effects. Although there is a lot of literature on bitter gourd as an anti-diabetic agent, very few papers discuss the anti-inflammatory and anti-cancer properties of this plant.Cancer is the second leading cause of death worldwide. Many plant food products have shown promising anticancer effects.Bitter melon or bitter gourd (Momordica charantia) is a nutrient-rich medicinal plant grown in tropical and subtropical regions of many countries.Bitter melon, which has traditionally been used as a folk medicine, contains many bioactive components such as triterpenoids, triterpene glycosides, phenolic acids, flavonoids, lectins, sterols, and proteins, which can potentially be used without serious side effects.It shows strong anti-cancer effects.The preventive and therapeutic effects of crude extracts or isolated components have been studied in cell line-based and animal models of various types of cancer.This review summarizes recent advances in testing the cancer preventive and therapeutic effects of bitter gourd, focusing on the underlying molecular mechanisms.The crude extract and its components prevent many types of cancer by promoting the formation of reactive oxygen species. Inhibition of cancer cell cycle, cell signaling, cancer stem cells, glucose and lipid metabolism, invasion, metastasis, hypoxia and angiogenesis. Inducing apoptosis and autophagy cell death, as well as improving immunological protection. As a result, bitter melon has the potential to be a cancer preventative and therapeutic agent.

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JANVI SANTOSH NADEKAR & Mrs. Bhagyashree koli chaudhary (July-2024). Momordica charantia, a Nutraceutical Approach for Inflammatory Related Disease(Cancer). INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(7), b263-b272. https://ijnrd.org/papers/IJNRD2407129.pdf

Volume 9 Issue 7, July-2024

Pages : b263-b272

Paper Reg. ID: IJNRD_224731

Published Paper Id: IJNRD2407129

Downloads: 000121997

Research Area: Pharmacy

Country: Kalyan, Maharashtra, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2407129.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2407129

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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