Paper Title
Enhanced Solubility and Dissolution by Drug-drug Cocrystals: A Comprehensive Review
Article Identifiers
: Authors
Keywords
Pharmaceutical cocrystals, solubility, dissolution, solid-state strategies, physicochemical properties, bioavailability, drug development, FDA guidelines, EMA guidelines.
Abstract
Physicochemical properties such as stability, particle size, powder flowability, taste, hygroscopicity, solubility, and compatibility of active pharmaceutical ingredients (APIs) are critical for the therapeutic efficacy and production costs of solid dosage forms. Oral drug delivery systems largely depend on the solubility and dissolution rates of drug molecules, with many drugs exhibiting low water solubility and bioavailability. To address these issues, several solid-state strategies have been employed, including salts, polymorphs, hydrates, solvates, and cocrystals. Among these, pharmaceutical cocrystals have gained significant attention for their ability to improve the physicochemical properties of APIs without altering their pharmacological nature. Cocrystals, which consist of two or more neutral molecules in a stoichiometric ratio linked by noncovalent bonds, have shown promise in enhancing drug solubility, stability, and bioavailability. Regulatory authorities, including the FDA and EMA, have recognized the importance of cocrystals, providing guidelines for their classification and application. This review summarizes the preparation methods, physicochemical property modulation, and applications of pharmaceutical cocrystals, highlighting their role in advancing drug development.
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How To Cite (APA)
Siddhesh Sunil Tamboli, Khushal Bisan Rathod, Deep Prashant Raut, Aniket Neelesh Timble, & Gayatri Kishore Panigrahi (July-2024). Enhanced Solubility and Dissolution by Drug-drug Cocrystals: A Comprehensive Review. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(7), b24-b37. https://ijnrd.org/papers/IJNRD2407103.pdf
Issue
Volume 9 Issue 7, July-2024
Pages : b24-b37
Other Publication Details
Paper Reg. ID: IJNRD_224836
Published Paper Id: IJNRD2407103
Downloads: 000122256
Research Area: Pharmacy
Author Type: Indian Author
Country: Bicholim, Goa, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2407103.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2407103
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