Formulation and Evaluation of Mouth Dissolving Tablets - Propranolol HCl

Formulation and Evaluation of Mouth Dissolving Tablets - Propranolol HCl

Registration ID: IJNRD_224781

Published ID: IJNRD2407095

DOI: Click Here to Get

SWAPNIL R DUDHAKOHAR , SHRADDHA R WASNIK , RATIKESH A WAWARKAR , YOGESH N NIKALAJE

Propranolol HCl, Mouth dissolving tablets, Super disintegrants, Direct compression.

Mouth dissolving tablets are patient friendly dosage form that rapidly disintegrate in mouth without need of water. In this present formulation the main objective is to develop mouth dissolving tablets of Propranolol HCl. Propranolol HCl is a β-adrenergic receptor antagonist, it blocks the action of epinephrine and nor epinephrine on both β1- and β2-adrenergic receptors. The present study investigates to development of novel fast dissolving tablet of Propranolol HCl which was by first pass metabolism, rapid disintegration, dissolution/absorption, and further improving the bioavailability of the drugs. The Mouth dissolving tablets were prepared by Direct compression methods using by using super disintegrants like Crospovidone XL, Sodium Carboxymethyl Starch, Pregelatinized starch in several concentrations. The prepared batches of tablets were evaluated post-compression parameters like weight variations, thickness, hardness, friability, drug content, disintegration time, and in-vitro dissolution. The optimized formulation of f5 mouth dissolving tablet containing Crospovidone XL showed maximum cumulative amount of drug release 97.5% in 11min and disintegration time 11sec. Propranolol HCl mouth dissolving tablet containing 9% Crospovidone XL exhibit the lowest disintegration time and rapid drug release compared with other super disintegrants.

Published Paper   E-Certificate

"Formulation and Evaluation of Mouth Dissolving Tablets - Propranolol HCl ", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.9, Issue 7, page no.a391-a398, July-2024, Available :https://ijnrd.org/papers/IJNRD2407095.pdf

Volume 9 Issue 7, July-2024

Pages : a391-a398

Paper Reg. ID: IJNRD_224781

Published Paper Id: IJNRD2407095

Downloads: 000121166

Research Area: Pharmacy

Country: Nagpur, Maharastra, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2407095.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2407095

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJNRD (IJ Publication) Janvi Wave

This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition

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