Paper Title
Formulation and Evaluation of Mouth Dissolving Tablets - Propranolol HCl
Article Identifiers
Authors
SWAPNIL R DUDHAKOHAR , SHRADDHA R WASNIK , RATIKESH A WAWARKAR , YOGESH N NIKALAJE
Keywords
Propranolol HCl, Mouth dissolving tablets, Super disintegrants, Direct compression.
Abstract
Mouth dissolving tablets are patient friendly dosage form that rapidly disintegrate in mouth without need of water. In this present formulation the main objective is to develop mouth dissolving tablets of Propranolol HCl. Propranolol HCl is a β-adrenergic receptor antagonist, it blocks the action of epinephrine and nor epinephrine on both β1- and β2-adrenergic receptors. The present study investigates to development of novel fast dissolving tablet of Propranolol HCl which was by first pass metabolism, rapid disintegration, dissolution/absorption, and further improving the bioavailability of the drugs. The Mouth dissolving tablets were prepared by Direct compression methods using by using super disintegrants like Crospovidone XL, Sodium Carboxymethyl Starch, Pregelatinized starch in several concentrations. The prepared batches of tablets were evaluated post-compression parameters like weight variations, thickness, hardness, friability, drug content, disintegration time, and in-vitro dissolution. The optimized formulation of f5 mouth dissolving tablet containing Crospovidone XL showed maximum cumulative amount of drug release 97.5% in 11min and disintegration time 11sec. Propranolol HCl mouth dissolving tablet containing 9% Crospovidone XL exhibit the lowest disintegration time and rapid drug release compared with other super disintegrants.
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How To Cite (APA)
SWAPNIL R DUDHAKOHAR, SHRADDHA R WASNIK, RATIKESH A WAWARKAR, & YOGESH N NIKALAJE (July-2024). Formulation and Evaluation of Mouth Dissolving Tablets - Propranolol HCl . INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(7), a391-a398. https://ijnrd.org/papers/IJNRD2407095.pdf
Issue
Volume 9 Issue 7, July-2024
Pages : a391-a398
Other Publication Details
Paper Reg. ID: IJNRD_224781
Published Paper Id: IJNRD2407095
Downloads: 000121992
Research Area: Pharmacy
Country: Nagpur, Maharastra, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2407095.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2407095
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Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)
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This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition
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