RP-HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF METFORMIN AND CANAGLIFLOZIN IN PHARMACEUTICAL DOSAGE FORM

RP-HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF METFORMIN AND CANAGLIFLOZIN IN PHARMACEUTICAL DOSAGE FORM

Registration ID: IJNRD_224649

Published ID: IJNRD2407043

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Paidimarri Vivek Sagar , Kanthi Silpa , K Sirisha

A novel, rapid, and accurate RP-HPLC method was developed and validated for the simultaneous estimation of Metformin and Canagliflozin in their API and pharmaceutical dosage form. The detection wavelength was selected at 240 nm based on the overlay spectra of individual drugs. The chromatographic separation was achieved on a Symmetry C-18 column (4.6×150mm) 5µ column with a mobile phase consisting of methanol: pH 3 phosphate buffer (70: 30 % v/v) at a flow rate of [Flow Rate] mL/min. The retention times for Metformin and Canagliflozin were found to be 2.406 and 3.973 minutes, respectively. The method demonstrated good system suitability parameters with theoretical plates exceeding 2200 and tailing factors less than 1.3. The resolution between the peaks was 8.67, ensuring efficient separation. The developed method exhibited excellent linearity (correlation coefficient > 0.999) across a broad concentration range. The accuracy study confirmed high recovery of both drugs (around 99.5%) within the acceptable range (98-102%). Furthermore, the method demonstrated robustness by maintaining acceptable performance when subjected to slight variations in flow rate (±0.2 mL/min) and organic modifier composition (±5%) in the mobile phase. This robust, validated RP-HPLC method can be effectively employed for the routine analysis of Metformin and Canagliflozin in bulk and pharmaceutical formulations.

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"RP-HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF METFORMIN AND CANAGLIFLOZIN IN PHARMACEUTICAL DOSAGE FORM", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.9, Issue 7, page no.a420-a431, July-2024, Available :https://ijnrd.org/papers/IJNRD2407043.pdf

Volume 9 Issue 7, July-2024

Pages : a420-a431

Paper Reg. ID: IJNRD_224649

Published Paper Id: IJNRD2407043

Downloads: 000121186

Research Area: Pharmacy

Country: Hyderabad, Telangana, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2407043.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2407043

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

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This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition

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