Nano Pharmaceutical for diabetes Management using plant Extract.

Nano Pharmaceutical for diabetes Management using plant Extract.

Registration ID: IJNRD_224055

Published ID: IJNRD2406408

DOI: Click Here to Get

Miss.Anushka M. Chavan , Prof. Waghmare S.U , Miss. Dipali B. Hiwarde , Miss Rushali J. Gore , Miss. Aishwarya B. Bodkhe

Keywords: Phytosome, Diabetes Mellitus,formulation

Type 2 diabetes mellitus (T2DM) is a significant global health concern. Guava, scientifically known as Psidium guajava L., is widely used in traditional medicine and cooking. Previous research has shown its anti-inflammatory and anti-diabetic properties, although the underlying mechanisms remain unclear. This study examined the potential therapeutic effects of guava leaf extract on T2DM using both animal and cell culture models. Over a 12-week period, diabetic mice were administered guava leaf extract orally. The results indicate improved insulin sensitivity and glucose tolerance, along with a significant decrease in fasting plasma glucose levels. Furthermore, the extract reduced the expression of genes involved in gluconeogenesis and promoted glycogen buildup in the liver, as well as enhanced glucose uptake. Moreover, treatment with GvAEx led to elevated expression of glucose transporter 2 (GLUT2) on the hepatocyte membrane. Additionally, we have elucidated, for the first time, the potential mechanism behind the hypoglycemic effect of GvAEx involving the intestinal microbiota. GvAEx induced significant changes in the gut microbiota composition, increasing the abundance of the Lachnospiraceae family and Akkermansia genus, which are known to produce short-chain fatty acids (SCFAs). These findings suggest that GvAEx may mitigate hyperglycemia and insulin resistance in T2DM by modulating liver glucose metabolism and restoring gut microbiota balance. Therefore, GvAEx shows promise for the development of therapeutics targeting T2DM.

Published Paper   E-Certificate

"Nano Pharmaceutical for diabetes Management using plant Extract.", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.9, Issue 6, page no.e137-e154, June-2024, Available :https://ijnrd.org/papers/IJNRD2406408.pdf

Volume 9 Issue 6, June-2024

Pages : e137-e154

Paper Reg. ID: IJNRD_224055

Published Paper Id: IJNRD2406408

Downloads: 000121167

Research Area: Pharmacy

Country: Chh.sambhajinagar, Maharashtra, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2406408.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2406408

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJNRD (IJ Publication) Janvi Wave

This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition

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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (IJNRD) aims to explore advances in research pertaining to applied, theoretical and experimental Technological studies. The goal is to promote scientific information interchange between researchers, developers, engineers, students, and practitioners working in and around the world. IJNRD will provide an opportunity for practitioners and educators of engineering field to exchange research evidence, models of best practice and innovative ideas.

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