Paper Title
Anti-Diabetic In-Vivo Animal Models: A Review
Article Identifiers
Authors
Avinash Bichave , Tejaswi Bandgar , Rina Kadu , Shruti Khopkar , Shrutika Patil
Keywords
Diabetes mellitus, In-vivo animal models, Type 1 diabetes, Type 2 diabete Keywords: Diabetes mellitus, In-vivo animal models, Type 1 diabetes, Type 2 diabetes.
Abstract
Diabetes mellitus is a chronic metabolic disorder with severe health implications, characterized by persistent hyperglycemia due to insufficient insulin production or impaired insulin action. The aim of this review is to provide a comprehensive overview of in-vivo animal models used in diabetes research, which are essential for understanding the disease mechanisms and developing new therapeutic interventions. This review explores the classification of diabetes, emphasizing the need for appropriate animal models that accurately mimic human diabetes conditions. Key models discussed include Non-Obese Diabetic (NOD) mice for Type 1 diabetes and Zucker Diabetic Fatty (ZDF) rats for Type 2 diabetes, among others. The review highlights the strengths and limitations of various models, discussing their respective advantages and applications in studying different aspects of diabetes. Additionally, it addresses the critical ethical considerations involved in animal research, focusing on the principles of Replacement, Reduction, and Refinement (3Rs). Advances in genetic manipulation techniques, such as CRISPR/Cas9, and the development of humanized models are also reviewed, showcasing their potential to enhance the relevance and applicability of animal models in diabetes research. Ultimately, this review aims to guide researchers in selecting suitable animal models for their studies, thereby contributing to the development of effective treatments and interventions for diabetes
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How To Cite (APA)
Avinash Bichave, Tejaswi Bandgar, Rina Kadu, Shruti Khopkar, & Shrutika Patil (June-2024). Anti-Diabetic In-Vivo Animal Models: A Review. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(6), d776-d784. https://ijnrd.org/papers/IJNRD2406368.pdf
Issue
Volume 9 Issue 6, June-2024
Pages : d776-d784
Other Publication Details
Paper Reg. ID: IJNRD_224142
Published Paper Id: IJNRD2406368
Downloads: 000121981
Research Area: Pharmacy
Country: Raigad, Maharashtra, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2406368.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2406368
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Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)
ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016
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Licence
This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition


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