Paper Title

Anti-Diabetic In-Vivo Animal Models: A Review

Article Identifiers

Registration ID: IJNRD_224142

Published ID: IJNRD2406368

DOI: Click Here to Get

Authors

Avinash Bichave , Tejaswi Bandgar , Rina Kadu , Shruti Khopkar , Shrutika Patil

Keywords

Diabetes mellitus, In-vivo animal models, Type 1 diabetes, Type 2 diabete Keywords: Diabetes mellitus, In-vivo animal models, Type 1 diabetes, Type 2 diabetes.

Abstract

Diabetes mellitus is a chronic metabolic disorder with severe health implications, characterized by persistent hyperglycemia due to insufficient insulin production or impaired insulin action. The aim of this review is to provide a comprehensive overview of in-vivo animal models used in diabetes research, which are essential for understanding the disease mechanisms and developing new therapeutic interventions. This review explores the classification of diabetes, emphasizing the need for appropriate animal models that accurately mimic human diabetes conditions. Key models discussed include Non-Obese Diabetic (NOD) mice for Type 1 diabetes and Zucker Diabetic Fatty (ZDF) rats for Type 2 diabetes, among others. The review highlights the strengths and limitations of various models, discussing their respective advantages and applications in studying different aspects of diabetes. Additionally, it addresses the critical ethical considerations involved in animal research, focusing on the principles of Replacement, Reduction, and Refinement (3Rs). Advances in genetic manipulation techniques, such as CRISPR/Cas9, and the development of humanized models are also reviewed, showcasing their potential to enhance the relevance and applicability of animal models in diabetes research. Ultimately, this review aims to guide researchers in selecting suitable animal models for their studies, thereby contributing to the development of effective treatments and interventions for diabetes

How To Cite (APA)

Avinash Bichave, Tejaswi Bandgar, Rina Kadu, Shruti Khopkar, & Shrutika Patil (June-2024). Anti-Diabetic In-Vivo Animal Models: A Review. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(6), d776-d784. https://ijnrd.org/papers/IJNRD2406368.pdf

Issue

Volume 9 Issue 6, June-2024

Pages : d776-d784

Other Publication Details

Paper Reg. ID: IJNRD_224142

Published Paper Id: IJNRD2406368

Downloads: 000121981

Research Area: Pharmacy

Country: Raigad, Maharashtra, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2406368.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2406368

About Publisher

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

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Call For Paper

Call For Paper - Volume 10 | Issue 10 | October 2025

IJNRD is a Scholarly Open Access, Peer-reviewed, and Refereed Journal with a High Impact Factor of 8.76 (calculated by Google Scholar & Semantic Scholar | AI-Powered Research Tool). It is a Multidisciplinary, Monthly, Low-Cost Journal that follows UGC CARE 2025 Peer-Reviewed Journal Policy norms, Scopus journal standards, and Transparent Peer Review practices to ensure quality and credibility. IJNRD provides indexing in all major databases & metadata repositories, a citation generator, and Digital Object Identifier (DOI) for every published article with full open-access visibility.

The INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (IJNRD) aims to advance applied, theoretical, and experimental research across diverse fields. Its goal is to promote global scientific information exchange among researchers, developers, engineers, academicians, and practitioners. IJNRD serves as a platform where educators and professionals can share research evidence, models of best practice, and innovative ideas, contributing to academic growth and industry relevance.

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Important Dates for Current issue

Paper Submission Open For: October 2025

Current Issue: Volume 10 | Issue 10 | October 2025

Impact Factor: 8.76

Last Date for Paper Submission: Till 31-Oct-2025

Notification of Review Result: Within 1-2 Days after Submitting paper.

Publication of Paper: Within 01-02 Days after Submititng documents.

Frequency: Monthly (12 issue Annually).

Journal Type: IJNRD is an International Peer-reviewed, Refereed, and Open Access Journal with Transparent Peer Review as per the new UGC CARE 2025 guidelines, offering low-cost multidisciplinary publication with Crossref DOI and global indexing.

Subject Category: Research Area

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