“Development & Characterization of PLGA-Based Voriconazole Nanosuspension for Opthalmic Application ’’

Registration ID: IJNRD_223826

Published ID: IJNRD2406304

DOI: Click Here to Get

DIPALI RAJENDRA KHANDAGALE , Dr.P.K.Pawar

VCZNS. PLGA, NS,EE.

Abstract The objective of present incvestigation to develop and characterize PLGA based voriconazole nanosuspension for the treatment of occuular keratitis. PLGA polymer (75:25) were used to prepare voriconazole loaded nanosuspension by using solvent evaporation technique and characterized physicochemical properties, like particle size, zeta potential and entrapment efficiency, in vitro drug release.. All the formulations of voriconazole loaded nanosuspension were also evaluated by in vitro drug release profile. The voriconazole loaded nanosuspension showed uniform particle size (around 167.01±05.00 nm to 491.31±18.94 nm) and shows high entrapment efficiency (78.23 ± 0.57 to 87.34± 0.52%.) and positive zeta potential for all batches. To improve their stability the optimized nanosuspension were lyophilized by using mannitol as a cryoprotectant confirmed that the drug was dispersed inside the particles and there is no only interaction between drug and polymer. The voriconazole was incorporated successfully in nanoparticles of nanosuspension prepared with 1:4 drug polymer ratios by using PLGA (75:25) which provide sustained release profile and follows zero order release kinetic.

Published Paper   E-Certificate

DIPALI RAJENDRA KHANDAGALE & Dr.P.K.Pawar (June-2024). “Development & Characterization of PLGA-Based Voriconazole Nanosuspension for Opthalmic Application ’’. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(6), d172-d182. https://ijnrd.org/papers/IJNRD2406304.pdf

Volume 9 Issue 6, June-2024

Pages : d172-d182

Paper Reg. ID: IJNRD_223826

Published Paper Id: IJNRD2406304

Downloads: 000121984

Research Area: Pharmacy

Country: pune, Maharashtra, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2406304.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2406304

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJNRD (IJ Publication) Janvi Wave | IJNRD.ORG | IJNRD.COM | IJPUB.ORG

This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition

Call For Paper - Volume 10 | Issue 10 | October 2025

IJNRD is a Scholarly Open Access, Peer-reviewed, and Refereed Journal with a High Impact Factor of 8.76 (calculated by Google Scholar & Semantic Scholar | AI-Powered Research Tool). It is a Multidisciplinary, Monthly, Low-Cost Journal that follows UGC CARE 2025 Peer-Reviewed Journal Policy norms, Scopus journal standards, and Transparent Peer Review practices to ensure quality and credibility. IJNRD provides indexing in all major databases & metadata repositories, a citation generator, and Digital Object Identifier (DOI) for every published article with full open-access visibility.

The INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (IJNRD) aims to advance applied, theoretical, and experimental research across diverse fields. Its goal is to promote global scientific information exchange among researchers, developers, engineers, academicians, and practitioners. IJNRD serves as a platform where educators and professionals can share research evidence, models of best practice, and innovative ideas, contributing to academic growth and industry relevance.

Indexing Coverage includes Google Scholar, SSRN, ResearcherID-Publons, Semantic Scholar (AI-Powered Research Tool), Microsoft Academic, Academia.edu, arXiv.org, ResearchGate, CiteSeerX, ResearcherID (Thomson Reuters), Mendeley, DocStoc, ISSUU, Scribd, and many more recognized academic repositories.

How to submit the paper?

By Our website

Click Here to Submit Paper Online

By Mail

Send your paper to editor@ijnrd.org

Important Dates for Current issue

Paper Submission Open For: October 2025

Current Issue: Volume 10 | Issue 10 | October 2025

Impact Factor: 8.76

Last Date for Paper Submission: Till 31-Oct-2025

Notification of Review Result: Within 1-2 Days after Submitting paper.

Publication of Paper: Within 01-02 Days after Submititng documents.

Frequency: Monthly (12 issue Annually).

Journal Type: IJNRD is an International Peer-reviewed, Refereed, and Open Access Journal with Transparent Peer Review as per the new UGC CARE 2025 guidelines, offering low-cost multidisciplinary publication with Crossref DOI and global indexing.

Subject Category: Research Area

Call for Paper: More Details