“Development & Characterization of PLGA-Based Voriconazole Nanosuspension for Opthalmic Application ’’

“Development & Characterization of PLGA-Based Voriconazole Nanosuspension for Opthalmic Application ’’

Registration ID: IJNRD_223826

Published ID: IJNRD2406304

DOI: Click Here to Get

DIPALI RAJENDRA KHANDAGALE , Dr.P.K.Pawar

VCZNS. PLGA, NS,EE.

Abstract The objective of present incvestigation to develop and characterize PLGA based voriconazole nanosuspension for the treatment of occuular keratitis. PLGA polymer (75:25) were used to prepare voriconazole loaded nanosuspension by using solvent evaporation technique and characterized physicochemical properties, like particle size, zeta potential and entrapment efficiency, in vitro drug release.. All the formulations of voriconazole loaded nanosuspension were also evaluated by in vitro drug release profile. The voriconazole loaded nanosuspension showed uniform particle size (around 167.01±05.00 nm to 491.31±18.94 nm) and shows high entrapment efficiency (78.23 ± 0.57 to 87.34± 0.52%.) and positive zeta potential for all batches. To improve their stability the optimized nanosuspension were lyophilized by using mannitol as a cryoprotectant confirmed that the drug was dispersed inside the particles and there is no only interaction between drug and polymer. The voriconazole was incorporated successfully in nanoparticles of nanosuspension prepared with 1:4 drug polymer ratios by using PLGA (75:25) which provide sustained release profile and follows zero order release kinetic.

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"“Development & Characterization of PLGA-Based Voriconazole Nanosuspension for Opthalmic Application ’’", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.9, Issue 6, page no.d172-d182, June-2024, Available :https://ijnrd.org/papers/IJNRD2406304.pdf

Volume 9 Issue 6, June-2024

Pages : d172-d182

Paper Reg. ID: IJNRD_223826

Published Paper Id: IJNRD2406304

Downloads: 000121175

Research Area: Pharmacy

Country: pune, Maharashtra, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2406304.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2406304

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJNRD (IJ Publication) Janvi Wave

This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition

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