“Development & Characterization of PLGA-Based Voriconazole Nanosuspension for Opthalmic Application ’’

Registration ID: IJNRD_223826

Published ID: IJNRD2406304

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DIPALI RAJENDRA KHANDAGALE, Dr.P.K.Pawar

VCZNS. PLGA, NS,EE.

Abstract The objective of present incvestigation to develop and characterize PLGA based voriconazole nanosuspension for the treatment of occuular keratitis. PLGA polymer (75:25) were used to prepare voriconazole loaded nanosuspension by using solvent evaporation technique and characterized physicochemical properties, like particle size, zeta potential and entrapment efficiency, in vitro drug release.. All the formulations of voriconazole loaded nanosuspension were also evaluated by in vitro drug release profile. The voriconazole loaded nanosuspension showed uniform particle size (around 167.01±05.00 nm to 491.31±18.94 nm) and shows high entrapment efficiency (78.23 ± 0.57 to 87.34± 0.52%.) and positive zeta potential for all batches. To improve their stability the optimized nanosuspension were lyophilized by using mannitol as a cryoprotectant confirmed that the drug was dispersed inside the particles and there is no only interaction between drug and polymer. The voriconazole was incorporated successfully in nanoparticles of nanosuspension prepared with 1:4 drug polymer ratios by using PLGA (75:25) which provide sustained release profile and follows zero order release kinetic.

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DIPALI RAJENDRA KHANDAGALE & Dr.P.K.Pawar (June-2024). “Development & Characterization of PLGA-Based Voriconazole Nanosuspension for Opthalmic Application ’’. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(6), d172-d182. https://ijnrd.org/papers/IJNRD2406304.pdf

Volume 9 Issue 6, June-2024

Pages : d172-d182

Paper Reg. ID: IJNRD_223826

Published Paper Id: IJNRD2406304

Downloads: 000122256

Research Area: Pharmacy

Author Type: Indian Author

Country: pune, Maharashtra, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2406304.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2406304

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