Solubility enhancement of poorly water soluble Quinine Sulphate by complexation with Beta Cyclodextrin and it’s derivatives.

Registration ID: IJNRD_223821

Published ID: IJNRD2406303

DOI: Click Here to Get

Shreeya Vijay Bhujbal , Pratiksha Ramesh Gadekar , Rushieksh Rajendra Dukare , Aniket Gopal Fulsundar , Aniket Vikram Gadge

Quinine Sulphate, Inclusion complexation, Cyclodextrins, Solubility, Dissolution.

The objectives of the study were to enhance the effects of β-cyclodextrin (βCD) and hydroxypropyl-β-cyclodextrin (HPβCD) on the solubility and dissolution rate of Quinine Sulphate prepared using three different methods, at drug to cyclodextrin weight ratios of 1:1, 1:2, 1:3. All the methods increased the solubility and dissolution rate of Quinine Sulphate via inclusion complexation with βCD and HPβCD. Quinine Sulphate was converted from crystalline to amorphous form through inclusion complexation. Solvent evaporation method was the most effective method in terms of Quinine Sulphate solubilisation, while inclusion complex of HPβCD has higher solubility than βCD complex when prepared using the same procedure

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Shreeya Vijay Bhujbal, Pratiksha Ramesh Gadekar, Rushieksh Rajendra Dukare, Aniket Gopal Fulsundar, & Aniket Vikram Gadge (June-2024). Solubility enhancement of poorly water soluble Quinine Sulphate by complexation with Beta Cyclodextrin and it’s derivatives.. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(6), d154-d171. https://ijnrd.org/papers/IJNRD2406303.pdf

Volume 9 Issue 6, June-2024

Pages : d154-d171

Paper Reg. ID: IJNRD_223821

Published Paper Id: IJNRD2406303

Downloads: 000122004

Research Area: Pharmacy

Country: badlapur, Maharashtra, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2406303.pdf

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