Paper Title
Formulation And Evaluation of Telmisartan Gastro retentive drug delivery systems
Article Identifiers
Registration ID: IJNRD_223646
Published ID: IJNRD2406244
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Keywords
Floating, Pulsatile, Circadian rhythm, compression, gastric retention
Abstract
Pulsatile drug delivery systems are a novel drug delivery system that is gaining a lot of attention because they deliver the drug to the right site of action at the right time and in the right amount, providing spatial and temporal delivery and increasing patient compliance, enhancing bioavailability and prolonging residence time in the stomach, and holding out good prospects for helping patients with chronic conditions like arthritis, asthma, hypertension, and others. The goal of the current study was to create a floating pulsatile drug delivery system that would achieve no drug release when floating and then pulsed, fast medication release. These systems were created to work with the body's natural circadian cycle. Compression coated floating pulsatile medication delivery for Telmisartan was the focus of the current research project. The floating pulsatile concept was used to extend the stomach residence time of a dose form with a lag phase and burst release. Due to the increased risk of heart attacks in people with hypertension in the morning, drug delivery systems that release medications in the morning and offer effective treatment were required. Rapid release core tablets were directly compressed into tablet form, and the core tablets were then top-coated with a buoyant coating of HPMC. For the layer of pulsatile coating, different grades of HPMC polymer were employed. Physical features of the produced formulations were assessed using DSC and XRD Studies on in vitro dissolution, floating lag time, floating time, release lag time, and drug content. The technique demonstrated a superb lag phase, which was followed by a burst release in the distal small intestine. This allows for site- and time-specific delivery of Telmisartan, which acts as chronotherapy for the treatment of hypertension.
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How To Cite (APA)
Shreyas Pethkar, Rutuja Mali, Omkar Gongane, Pritham Salokhe, & Nilesh Chougule (June-2024). Formulation And Evaluation of Telmisartan Gastro retentive drug delivery systems. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(6), c427-c445. https://ijnrd.org/papers/IJNRD2406244.pdf
Issue
Volume 9 Issue 6, June-2024
Pages : c427-c445
Other Publication Details
Paper Reg. ID: IJNRD_223646
Published Paper Id: IJNRD2406244
Research Area: Pharmacy
Author Type: Indian Author
Country: Islampur, Maharashtra, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2406244.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2406244
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