Drug Use Evaluation of Ceftriaxone in Nifas silk lafto w-01 Health Center

Registration ID: IJNRD_222001

Published ID: IJNRD2406214

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firaol tilahin alamu , mahlet abebe , getnet derero

antimicrobials, ceftriaxone, drug use evaluation; DUE, Ethiopia

Background Ceftriaxone is one of the most commonly used antibiotics due to its availability, wide spectrum of activity and low toxicity. However, irrational use of ceftriaxone is one of the current issues in most countries, especially developing ones. Objective The aim of this study was to evaluate ceftriaxone utilization in INPATINT wards of Nifas silk lafto w-01 HC in Ethiopia. Methods An institution-based retrospective cross-sectional study was conducted on randomly selected 1,0 patients who were admitted to NSLW01HC from TIRE 2016 to MAGBATE 2016. A structured data abstraction format was used to collect data from patients’ Card patient. Medscape® drug interaction checker was used to identify significant drug–drug interactions, and national and international guidelines ,STG ,EPHCCG ,were used to evaluate the appropriateness of ceftriaxone use. The data were analyzed by using SPSS version 20.0. Results Among the 103 patients enrolled, ceftriaxone was utilized by 53 (51.7%) patients, and these patients were considered for evaluation of appropriateness and subsequent analysis. Among 53patients, ceftriaxone was used for empiric therapy in 47 (60.2%) patients; of which, were for prophylaxis 10 (99.2%) ,In the majority of the patients, the dose of ceftriaxone was 1g/day 472 (78.6%) and for a duration of 2–7 days 409 (68.1%). Inappropriate use of ceftriaxone was observed among 237 (39.4%) patients with regard to indication, dose/frequency and duration. About half (49.3%) of the deviation from the guidelines was observed from surgical and gynecologic/obstetrics wards. Among the co-prescribed medications with ceftriaxone, ringer lactate, Vitamine B COMPLEX and were found to have a significant drug–drug interaction. Conclusion This study revealed that inappropriate use of ceftriaxone was high in NSLW01HC . This may increase the emergence of resistant pathogens which may lead to treatment failure and increase cost of therapy. Therefore, adherence to current evidence-based guidelines is recommended.

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firaol tilahin alamu, mahlet abebe , & getnet derero (June-2024). Drug Use Evaluation of Ceftriaxone in Nifas silk lafto w-01 Health Center. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(6), c138-c147. https://ijnrd.org/papers/IJNRD2406214.pdf

Volume 9 Issue 6, June-2024

Pages : c138-c147

Paper Reg. ID: IJNRD_222001

Published Paper Id: IJNRD2406214

Downloads: 000121977

Research Area: Pharmacy

Country: addisa ababa, ethiopa, Ethiopia

Published Paper PDF: https://ijnrd.org/papers/IJNRD2406214.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2406214

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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