Paper Title
Design, Development and Evaluation of in-situ Floating Gel of Canagliflozin
Article Identifiers
Authors
Dr. B.V.Ramana , K.Pujitha , P.Shahanaz, B.Haritha , K.Eswar Kumar , R.Sai Kiran Singh
Keywords
Canagliflozin, Diabetes, Sodium alginate, Sodium bicarbonate, Calcium carbonate, HPMC E-50.
Abstract
Canagliflozin an analogue of sodium -glucose co -transporter 2 (SGLT2) inhibitors . reduces the release of many neurotransmitters, including glutamate, and noradrenaline. It is used for the treatment of diabeties. The present research work aims to ensure a high drug absorption by retarding the advancement of canagliflozin formulation through the gastrointestinal tract. The work aims to design a controlled release canagliflozin formulation which is administered as liquid and further gels in the stomach and floats in gastric juice. Materials and Methods: In situ gelling formulations were prepared using sodium alginate, calcium carbonate, sodium Bicarbonate, hydroxyl propyl methylcellulose (HPMC) E-50M, and sodium bicarbonate. The prepared formulations were evaluated for solution viscosity, drug content, in vitro gelling studies, gel strength, and in vitro drug release. Results: The formulation containing 3% w/v sodium alginate and 0.6% w/v HPMC E-50 were considered optimum since it showed minimum floating lag time (65±0.24s), optimum viscosity (181 cps). The optimized formulation follows first ordering Higuchi kinetic model with regression value 0.9964 representing diffusion mechanism of drug release. Conclusion: Floating in situ gelling system of canagliflozin can be formulated using sodium alginate as a gelling polymer and calcium carbonate as a complexing agent to control the drug release for about 8 hrs for the treatment of diabeties.
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How To Cite (APA)
Dr. B.V.Ramana, K.Pujitha, P.Shahanaz, B.Haritha, K.Eswar Kumar, & R.Sai Kiran Singh (June-2024). Design, Development and Evaluation of in-situ Floating Gel of Canagliflozin. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(6), c78-c111. https://ijnrd.org/papers/IJNRD2406210.pdf
Issue
Volume 9 Issue 6, June-2024
Pages : c78-c111
Other Publication Details
Paper Reg. ID: IJNRD_219403
Published Paper Id: IJNRD2406210
Downloads: 000121977
Research Area: Pharmacy
Country: Kurnool, Andhra Pradesh, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2406210.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2406210
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Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)
ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016
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This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition
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