An Overview of Floating Drug Delivery Systems for Oral Bioavailability Enhancement

Registration ID: IJNRD_223430

Published ID: IJNRD2406146

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Animesh Dadheech, Anil Kumar Goyal, Rajesh Asija, Seema Yadav Trimukhe

Floating drug delivery systems, effervescent systems, hydrodynamically, oral bioavailability

Drug delivery systems play a crucial role in enhancing the therapeutic efficacy of drugs and maximizing patient compliance. Among various drug delivery systems, floating drug delivery systems have gained significant attention due to their ability to improve the oral bioavailability of poorly soluble drugs. This comprehensive review aims to provide an in-depth analysis of floating drug delivery systems and their potential in achieving good oral bioavailability. Floating drug delivery systems are designed to float on the gastric fluid for an extended period, thereby allowing sustained release of the drug and enhancing its absorption. Various approaches such as effervescent systems, hydrodynamically balanced systems, and raft-forming systems have been developed to achieve optimal floating properties. The holistic approach towards developing a successful floating drug delivery system involves a thorough understanding of factors affecting gastric emptying time, formulation parameters, and physicochemical properties of the drug. By considering these factors comprehensively, researchers can design a system that ensures maximum drug release at the desired site of action. Moreover, the use of novel polymers, excipients, and technologies has further enhanced the feasibility and effectiveness of floating drug delivery systems. These advancements offer promising opportunities for improving the oral bioavailability of a wide range of drugs with poor solubility and permeability. This review examines floating drug delivery systems, which are designed to improve oral bioavailability of poorly soluble drugs. These systems float on the gastric fluid for an extended period, allowing sustained drug release and enhanced absorption. Various approaches, including effervescent, hydrodynamically balanced, and raft-forming systems, have been developed to achieve optimal floating properties. A holistic approach to developing a successful system involves understanding factors affecting gastric emptying time, formulation parameters, and drug physicochemical properties. The use of novel polymers, excipients, and technologies has further enhanced the feasibility and effectiveness of floating drug delivery systems. This review emphasizes the potential of these systems to overcome challenges associated with poor solubility and absorption rates, ultimately improving therapeutic outcomes for patients.

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Animesh Dadheech, Anil Kumar Goyal, Rajesh Asija, & Seema Yadav Trimukhe (June-2024). An Overview of Floating Drug Delivery Systems for Oral Bioavailability Enhancement. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(6), b434-b440. https://ijnrd.org/papers/IJNRD2406146.pdf

Volume 9 Issue 6, June-2024

Pages : b434-b440

Paper Reg. ID: IJNRD_223430

Published Paper Id: IJNRD2406146

Downloads: 000122257

Research Area: Engineering

Author Type: Indian Author

Country: -, -, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2406146.pdf

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Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

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