Paper Title
A Review on use of Sublingual films and some other methods to increase the bioavailability of poorly soluble drugs
Article Identifiers
Authors
Prajapati Pawankumar Teekamchand , Anil Kumar Goyal , Rajesh Asija , Seema Yadav Trimukhe
Keywords
Sublingual films, microemulsions, Nanotechnology-based approaches, nanoemulsions and nanocrystals.
Abstract
Pharmaceutical researchers have long been exploring methods to increase the bioavailability of poorly soluble drugs, as this can significantly impact the effectiveness of a drug. One such method that has gained attention is the use of sublingual films. Sublingual films are thin strips that are placed under the tongue, allowing for rapid absorption of the drug into the bloodstream. This route bypasses first-pass metabolism in the liver, leading to higher bioavailability compared to traditional oral administration. The prodrug approach is an exciting way to improve the oral bioavailability of BCS class II drugs with low solubility and reasonable permeability, but extensive studies are needed to establish the safety profile of prodrugs in humans. Thin film drug delivery has emerged as an innovative alternative to traditional pills, capsules, and liquids commonly used for both prescription and over-the-counter medications. Dissolvable oral thin films (OTFs), also called Oral Strips (OS), originated in the confectionery and oral care industries as breath strips but have recently become a popular and innovative method for delivering vitamins and other personal care products. OTFs are gaining acceptance as a novel dosage form in pharmaceutical technology. ODFs may become the preferred delivery method for treatments requiring rapid absorption, such as those for pain, allergies, insomnia, and central neurological disorders. Self-emulsifying drug delivery systems are isotropic solutions of oil and surfactant that form oil-in-water microemulsions on mild agitation in the presence of water. SCF technologies are promising for eliminating organic solvent use in drug-cyclodextrin complexes. Overall, while sublingual films offer a convenient and effective method for increasing bioavailability of poorly soluble drugs, other innovative approaches like nanotechnology-based methods also hold potential for enhancing drug solubility and absorption. Nanotechnology-based approaches, such as nanoemulsions and nanocrystals, have shown promise in increasing drug dissolution rates and improving absorption. These techniques involve reducing drug particle size to enhance surface area and promote quicker dissolution.
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How To Cite (APA)
Prajapati Pawankumar Teekamchand, Anil Kumar Goyal, Rajesh Asija, & Seema Yadav Trimukhe (June-2024). A Review on use of Sublingual films and some other methods to increase the bioavailability of poorly soluble drugs. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(6), b106-b112. https://ijnrd.org/papers/IJNRD2406111.pdf
Issue
Volume 9 Issue 6, June-2024
Pages : b106-b112
Other Publication Details
Paper Reg. ID: IJNRD_223292
Published Paper Id: IJNRD2406111
Downloads: 000121988
Research Area: Engineering
Country: -, -, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2406111.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2406111
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Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)
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