Paper Title
FORMULATION AND EVALUATION ORAL SELF MICROEMULSIFYING DRUG DELIVERY SYSTEM OF EMPAGLIFLOZIN
Article Identifiers
Authors
Satyajit Sahoo , Sneha Kumari , Prasanna Pradhan , Hitesh Jain , Dhananjay Meshram
Keywords
SMEDDS, Simplex design, admixing, Empagliflozin
Abstract
Abstract: Empagliflozin loaded Self Microemulsifying Drug Delivery System was developed using eucalyptus oil, tween 80 and PEG 400 as the formulation components. Self Microemulsifying Drug Delivery System containing empagliflozin was formulated by simple admixing method with suitable excipients. Simple Lattice Design was employed to optimize the liquid SMEDDS of Empagliflozin. Surface plot and contour plot were presented for graphical representation of the effect of independent variable on % Transmittance and %CDR. Also for validation of generated mathematical model check point analysis was done. Optimized batches were prepared as per the above design (F1-F10) and evaluated for various parameters. Batches F4 and F8 were observed with good result of various evaluation (% transmittance, emulsification time, %drug content, %CDR). So, they were further evaluated for size, zeta potential, PDI and viscosity. F4 showed better result than F8.The result of F4 that is drug content = 96.20±0.220%, transmittance=98.04±0.860%, drug release= 91.82%, zeta potential= -15.1 mV, PDI= 0.467 and size= 65.5 nm. Optimize (F4) liquid SMEDDS follows Hixon-crowell model (R2= 0.9786) and First order (R2= 0.9682) release kinetics. Self Micro Emulsifying Drug Delivery System of Empagliflozin was successfully prepared in order to enhance the solubility and dissolution rate by incorporating the drug in a lipid vehicle.
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How To Cite (APA)
Satyajit Sahoo, Sneha Kumari, Prasanna Pradhan, Hitesh Jain, & Dhananjay Meshram (May-2024). FORMULATION AND EVALUATION ORAL SELF MICROEMULSIFYING DRUG DELIVERY SYSTEM OF EMPAGLIFLOZIN. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(5), g554-g564. https://ijnrd.org/papers/IJNRD2405662.pdf
Issue
Volume 9 Issue 5, May-2024
Pages : g554-g564
Other Publication Details
Paper Reg. ID: IJNRD_222349
Published Paper Id: IJNRD2405662
Downloads: 000121987
Research Area: Pharmacy
Country: Vadodara, Gujarat, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2405662.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2405662
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Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)
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