FORMULATION AND EVALUATION ORAL SELF MICROEMULSIFYING DRUG DELIVERY SYSTEM OF EMPAGLIFLOZIN

FORMULATION AND EVALUATION ORAL SELF MICROEMULSIFYING DRUG DELIVERY SYSTEM OF EMPAGLIFLOZIN

Registration ID: IJNRD_222349

Published ID: IJNRD2405662

DOI: Click Here to Get

Satyajit Sahoo , Sneha Kumari , Prasanna Pradhan , Hitesh Jain , Dhananjay Meshram

SMEDDS, Simplex design, admixing, Empagliflozin

Abstract: Empagliflozin loaded Self Microemulsifying Drug Delivery System was developed using eucalyptus oil, tween 80 and PEG 400 as the formulation components. Self Microemulsifying Drug Delivery System containing empagliflozin was formulated by simple admixing method with suitable excipients. Simple Lattice Design was employed to optimize the liquid SMEDDS of Empagliflozin. Surface plot and contour plot were presented for graphical representation of the effect of independent variable on % Transmittance and %CDR. Also for validation of generated mathematical model check point analysis was done. Optimized batches were prepared as per the above design (F1-F10) and evaluated for various parameters. Batches F4 and F8 were observed with good result of various evaluation (% transmittance, emulsification time, %drug content, %CDR). So, they were further evaluated for size, zeta potential, PDI and viscosity. F4 showed better result than F8.The result of F4 that is drug content = 96.20±0.220%, transmittance=98.04±0.860%, drug release= 91.82%, zeta potential= -15.1 mV, PDI= 0.467 and size= 65.5 nm. Optimize (F4) liquid SMEDDS follows Hixon-crowell model (R2= 0.9786) and First order (R2= 0.9682) release kinetics. Self Micro Emulsifying Drug Delivery System of Empagliflozin was successfully prepared in order to enhance the solubility and dissolution rate by incorporating the drug in a lipid vehicle.

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"FORMULATION AND EVALUATION ORAL SELF MICROEMULSIFYING DRUG DELIVERY SYSTEM OF EMPAGLIFLOZIN", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.9, Issue 5, page no.g554-g564, May-2024, Available :https://ijnrd.org/papers/IJNRD2405662.pdf

Volume 9 Issue 5, May-2024

Pages : g554-g564

Paper Reg. ID: IJNRD_222349

Published Paper Id: IJNRD2405662

Downloads: 000121132

Research Area: Pharmacy

Country: Vadodara, Gujarat, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2405662.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2405662

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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