Paper Title
CHARACTERIZATION AND COMPUTATIONAL ANALYSIS OF LIPASE INHIBITORS FROM PLANT SOURCES
Article Identifiers
Authors
Santhosh kumar V , Swetha E , Haji mohamed A , Mohammed Suhail S , Pavilan S and Ramya M
Keywords
Plant extracts, anti-lipase activity, para nitrophenyl palmitate
Abstract
Abstract: Obesity is primarily regarded as a disorder of lipid metabolism and the enzymes involved in this process could be selectively targeted to develop anti obesity drugs. The prevalence of obesity is increasing at an alarming rate, but unfortunately only a few medications are currently on the market. Orlistat is an anti-obesity drug which is already available in the market but it has side effects after prolong usage. The anti-obesity drugs extracted from natural compounds will not have any side effects. Since dietary lipids represent the major source of unwanted calories, specifically inhibiting triglyceride (TG) digestion forms a new solution for the reduction of fat absorption. The leaves of the plant samples (cashew, drumstick, fenugreek, keezhanelli, neem) with lipase inhibitory activity were choosen and extracted using Soxhlet extractor using Methanol as solvent. These extracts were analysed for lipase inhibitory activity using para nitrophenyl palmitate as substrate. These extracts with high inhibitory activity of lipase inhibition will be further characterized and studied for enzyme kinetics and computational analysis in future to identify the compound that inhibit the activity of Lipase.
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How To Cite (APA)
Santhosh kumar V, Swetha E, Haji mohamed A, Mohammed Suhail S, & Pavilan S and Ramya M (May-2024). CHARACTERIZATION AND COMPUTATIONAL ANALYSIS OF LIPASE INHIBITORS FROM PLANT SOURCES. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(5), f402-f415. https://ijnrd.org/papers/IJNRD2405544.pdf
Issue
Volume 9 Issue 5, May-2024
Pages : f402-f415
Other Publication Details
Paper Reg. ID: IJNRD_221775
Published Paper Id: IJNRD2405544
Downloads: 000121982
Research Area: Biological Science
Country: Coimbatore, Tamil Nadu, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2405544.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2405544
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