In Rats, Minocycline Prevents LPS-Induced Neuronal Death and Memory Impairment

Registration ID: IJNRD_221342

Published ID: IJNRD2405364

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Abhishek Kumar Singh , Naveen kumar maurya , Satendra Chauhan , Shubhangini Tripathi , Deepansha

Alzheimer's disease, memantine, neuroinflammation, minocycline, and cognitive decline

ABSTRACT- Numerous animal models have shown that minocycline has strong impacts on the architecture and functioning of the nervous system. Its neuroprotective qualities, however, after a single lipopolysaccharide (LPS) injection in an adult rat model remain unclear. This study examined the neuroprotective properties of minocycline in a rat model of LPS-induced neuroinflammation.. Methods: Five sets of fifty-year-old male Sprague Dawley rats were created: (i) LPS treated with distilled water, (ii) LPS treated with 25 mg/kg minocycline, and (iv) LPS treated with 50 mg/kg minocycline. treated LPS and (v) LPS treated with 10 mg/kg memantine. Day 5 was a single intraperitoneal injection of LPS (5 mg/kg), followed by daily injections of minocycline and memantine for a period of 14 days. Results: It was discovered that minocycline treatment significantly attenuated the effects of LPS on β-amyloid peptide buildup, neuronal damage, and memory loss. According to these findings, LPS causes neuronal damage and β-amyloid peptide buildup in the cortex and hippocampus, which subsequently affects cognitive memory. Additionally, we examined the administration of minocycline and memantine. The results indicated that, although minocycline (50 mg/kg) therapy produced superior outcomes, minocycline (25 mg/kg) and memantine (10 mg/kg) treatment were comparable. It lessens memory loss, neuronal damage, and beta-amyloid peptide formation brought on by LPS..

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Abhishek Kumar Singh, Naveen kumar maurya, Satendra Chauhan, Shubhangini Tripathi, & Deepansha (May-2024). In Rats, Minocycline Prevents LPS-Induced Neuronal Death and Memory Impairment. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(5), d585-d598. https://ijnrd.org/papers/IJNRD2405364.pdf

Volume 9 Issue 5, May-2024

Pages : d585-d598

Paper Reg. ID: IJNRD_221342

Published Paper Id: IJNRD2405364

Downloads: 000121991

Research Area: Pharmacy

Country: GORAKHPUR, UTTAR PRADESH, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2405364.pdf

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Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

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