DEVELOPMENT OF CRISPR/CAS9 GENE EDITING TECHNOLOGY

DEVELOPMENT OF CRISPR/CAS9 GENE EDITING TECHNOLOGY

Registration ID: IJNRD_218936

Published ID: IJNRD2405224

DOI: Click Here to Get

Pallavi Kakasaheb Lahane , Vaishnavi Kundalik Dawalbaje , Kirti Pandurang Kachole , Nikhil Vilas Nikam , Vivek Somnath Bhurke

Keywords: CRISPR/Cas 9,Genome editing, Gene therapy, Off target effects, RNA therapy, DNA, Cancer research, Animal model

CRISPR-Cas systems for genome editing have revolutionized life science research and hold significant potential for disease treatment and biotechnology advancements, transforming the way life science research is conducted. This ancient anti-viral immune system, found in bacteria and archaea, allows for precise targeted mutations, corrections, or gene modulation, enabling researchers to create targeted treatments. CRISPR/Cas9 may target genomic loci and be employed in cancer research to investigate tumourigenesis and development pathways. Prokaryotes have evolved defense mechanisms against viral predators, such as clustered regularly interspaced short palindromic repeats (CRISPR) and associated proteins (Cas), which have an adaptive immune system that remembers previous infections by incorporating invading genome sequences into the CRISPR locus. This article goes into the introduction, history, discovery & development, mechanism, applications, challenges, and essential components of CRISPR-Cas9, such as the Cas9 protein and guide RNA. It explores its applications in genetic manipulation, precision genome editing, personalised medicine, gene therapy, and agriculture. The purpose of this review is to enlighten readers about this novel prokaryotic adaptive immune system, and we expect that in the near future, this technology will be widely employed in clinics and research.

Published Paper   E-Certificate

"DEVELOPMENT OF CRISPR/CAS9 GENE EDITING TECHNOLOGY", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.9, Issue 5, page no.c193-c213, May-2024, Available :https://ijnrd.org/papers/IJNRD2405224.pdf

Volume 9 Issue 5, May-2024

Pages : c193-c213

Paper Reg. ID: IJNRD_218936

Published Paper Id: IJNRD2405224

Downloads: 000121199

Research Area: Pharmacy

Country: Chh.Sambhajinagar, Maharashtra, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2405224.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2405224

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJNRD (IJ Publication) Janvi Wave

This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition

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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (IJNRD) aims to explore advances in research pertaining to applied, theoretical and experimental Technological studies. The goal is to promote scientific information interchange between researchers, developers, engineers, students, and practitioners working in and around the world. IJNRD will provide an opportunity for practitioners and educators of engineering field to exchange research evidence, models of best practice and innovative ideas.

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