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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | Method Development and Validation of Anti- Coagulant Drug in Pharmaceutical Dosage Form by HPLC. |
| Authors Name: | Aditya Datir , Vijay M. Waghulkar , Dr. M. D. Game , Dr. M. P. Jadhav , S. G. Jawarkar |
| Download E-Certificate: | Download |
| Author Reg. ID: |
IJNRD_218858
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| Published Paper Id: | IJNRD2404726 |
| Published In: | Volume 9 Issue 4, April-2024 |
| DOI: | |
| Abstract: | ABSTRACT: The paper involves the development of a simple, Precise, and sensitive method for estimation of Apixaban in bulk drug and its marketed formulation using the reverse-phase liquid chromatographic method. The separation was achieved on C18 Hypersil-BDS Column (250 mm×4.6 mm×5 µm) using mobile phase (Methanol: Acetonitrile: Water: Glacial Acetic Acid) in the ratio of 65:15:20:0.5(v/v) with a run time of 7 minutes and wavelength for estimation of apixaban was taken as 277 nm. Literature survey reveals that there are very few HPLC methods were available using this composition of mobile phase Hence an attempt has been made to develop an RP-HPLC method for estimation of Apixaban. The developed method was validated for Accuracy, Precision, Linearity, System Suitability, LOD and LOQ, Robustness and Assay. The linearity was found to be in the range of 1-3 μg/ml with correlation coefficient found for linearity is 0.999. The developed and validated RP-HPLC method is applied for the identification of eluted. |
| Keywords: | Apixaban, Anti-Coagulant, HPLC, Method Development, Validation. |
| Cite Article: | "Method Development and Validation of Anti- Coagulant Drug in Pharmaceutical Dosage Form by HPLC.", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.9, Issue 4, page no.h215-h223, April-2024, Available :http://www.ijnrd.org/papers/IJNRD2404726.pdf |
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| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2404726 Registration ID: 218858 Published In: Volume 9 Issue 4, April-2024 DOI (Digital Object Identifier): Page No: h215-h223 Country: Morshi, Amravati, Maharashtra, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2404726 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2404726 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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