Paper Title
DEVELOPMENT AND VALIDATION OF HPLC METHOD FOR THE DETERMINATION OF HYDROCORTISONE SODIUM SUCCINATE
Article Identifiers
Authors
R.Radha , B.M.Guna sekhar , M.Kishore Babu , U.Nirupama , K.Nagaraju
Keywords
Hydrocortisone sodium succinate, High performance liquid chromatography, validation
Abstract
A simple, rapid, sensitive and linear HPLC method was developed for estimation of Hydrocortisone sodium succinate. In this method separation was carried out on HiQSil C8 column (250mm*4.6 mm, 5μm) using potassium dihydrogen orthophosphate Buffer pH 4 (adjusted with orthophosphoric acid) and ACN (30.:70 v/v) as mobile phase at flow rate of 1 ml/min. The quantification was carried out at 242 nm. The retention time (tR) of drug was 3.4 ± 0.10 min. The method was validated with respect to linearity, precision, assay, accuracy and robustness. The data of linear regression analysis indicated a good linear relationship over the range of 5-30 μg/ml concentrations with a correlation coefficient (r2) of 0.9914. Method can be used for routine analysis of compounds.
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How To Cite (APA)
R.Radha, B.M.Guna sekhar, M.Kishore Babu, U.Nirupama, & K.Nagaraju (April-2024). DEVELOPMENT AND VALIDATION OF HPLC METHOD FOR THE DETERMINATION OF HYDROCORTISONE SODIUM SUCCINATE. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(4), c124-c128. https://ijnrd.org/papers/IJNRD2404245.pdf
Issue
Volume 9 Issue 4, April-2024
Pages : c124-c128
Other Publication Details
Paper Reg. ID: IJNRD_214210
Published Paper Id: IJNRD2404245
Downloads: 000122004
Research Area: Engineering
Country: -, -, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2404245.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2404245
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