REVIEW ARTICLE ON ADVANCEMENTS IN MICRONEEDLE TECHNOLOGY

REVIEW ARTICLE ON ADVANCEMENTS IN MICRONEEDLE TECHNOLOGY

Registration ID: IJNRD_217432

Published ID: IJNRD2404090

DOI: Click Here to Get

Wankhede Tanuja , Deore Neha , Gosavi Siddhi

Microneedles, Transdermal drug delivery, minimally invasive, Fabrication techniques, Solid microneedles, Hollow microneedles, Coated microneedles, Dissolvable microneedle, Drug delivery applications, Biomedical advancements

Transdermal drug delivery (TDD) presents a promising avenue for drug administration, circumventing the limitations of oral intake and hypodermic injections. However, the stratum corneum, the outermost layer of the skin, poses a formidable barrier to efficient TDD. Microneedles, a technology evolving since the 1970s and refined with modern microfabrication techniques, offer a solution to this challenge. This review delves into the evolution, mechanisms, and applications of microneedle technology in enhancing transdermal drug delivery. Microneedles, ranging from solid to hollow, coated, and dissolvable, are engineered to penetrate the skin barrier effectively, facilitating drug delivery into the epidermis or dermis. Their minimally invasive nature, coupled with precise fabrication methods, ensures painless application and minimal tissue damage. Solid microneedles, fabricated from materials like silicon, metals, or polymers, create microchannels in the skin, enabling drug diffusion without the need for a hollow core. Hollow microneedles, on the other hand, offer continuous drug delivery through a bore at the needle's centre. Coated microneedles provide rapid drug delivery into the skin, while dissolvable microneedles gradually release drugs upon insertion, offering controlled dosing and enhanced patient compliance. Advancements in microneedle technology have led to their application in various fields, including drug delivery, vaccination, diagnostics, and cosmetic procedures. Coated and dissolvable microneedles show promise in rapid drug delivery and combination therapy, while solid microneedles are revolutionizing drug administration, diagnostics, and cosmetic treatments. Moreover, ongoing research aims to optimize microneedle fabrication methods, materials, and integration with wearable devices, paving the way for their widespread adoption in medical practice. microneedles represent a transformative approach to transdermal drug delivery, offering a versatile, minimally invasive platform for precise and efficient drug administration. With continued innovation, microneedles hold immense potential to enhance therapeutic outcomes, patient comfort, and healthcare delivery.(31)

Published Paper   E-Certificate

"REVIEW ARTICLE ON ADVANCEMENTS IN MICRONEEDLE TECHNOLOGY ", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.9, Issue 4, page no.a739-a764, April-2024, Available :https://ijnrd.org/papers/IJNRD2404090.pdf

Volume 9 Issue 4, April-2024

Pages : a739-a764

Paper Reg. ID: IJNRD_217432

Published Paper Id: IJNRD2404090

Downloads: 000121255

Research Area: Engineering

Country: -, -, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2404090.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2404090

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

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This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition

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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (IJNRD) aims to explore advances in research pertaining to applied, theoretical and experimental Technological studies. The goal is to promote scientific information interchange between researchers, developers, engineers, students, and practitioners working in and around the world. IJNRD will provide an opportunity for practitioners and educators of engineering field to exchange research evidence, models of best practice and innovative ideas.

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