INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016
Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI)
Transdermal drug delivery (TDD) presents a promising avenue for drug administration, circumventing the limitations of oral intake and hypodermic injections. However, the stratum corneum, the outermost layer of the skin, poses a formidable barrier to efficient TDD. Microneedles, a technology evolving since the 1970s and refined with modern microfabrication techniques, offer a solution to this challenge. This review delves into the evolution, mechanisms, and applications of microneedle technology in enhancing transdermal drug delivery.
Microneedles, ranging from solid to hollow, coated, and dissolvable, are engineered to penetrate the skin barrier effectively, facilitating drug delivery into the epidermis or dermis. Their minimally invasive nature, coupled with precise fabrication methods, ensures painless application and minimal tissue damage. Solid microneedles, fabricated from materials like silicon, metals, or polymers, create microchannels in the skin, enabling drug diffusion without the need for a hollow core. Hollow microneedles, on the other hand, offer continuous drug delivery through a bore at the needle's centre. Coated microneedles provide rapid drug delivery into the skin, while dissolvable microneedles gradually release drugs upon insertion, offering controlled dosing and enhanced patient compliance. Advancements in microneedle technology have led to their application in various fields, including drug delivery, vaccination, diagnostics, and cosmetic procedures. Coated and dissolvable microneedles show promise in rapid drug delivery and combination therapy, while solid microneedles are revolutionizing drug administration, diagnostics, and cosmetic treatments. Moreover, ongoing research aims to optimize microneedle fabrication methods, materials, and integration with wearable devices, paving the way for their widespread adoption in medical practice. microneedles represent a transformative approach to transdermal drug delivery, offering a versatile, minimally invasive platform for precise and efficient drug administration. With continued innovation, microneedles hold immense potential to enhance therapeutic outcomes, patient comfort, and healthcare delivery.(31)
"REVIEW ARTICLE ON ADVANCEMENTS IN MICRONEEDLE TECHNOLOGY ", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.9, Issue 4, page no.a739-a764, April-2024, Available :http://www.ijnrd.org/papers/IJNRD2404090.pdf
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2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
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