Paper Title
ANTI EPILEPTIC PROPERTIES OF CENTELLA ASIATICA AGAINST PENTYLENETETRAZOLE INDUCED EPILEPSY IN RATS WITH REFERENCE TO LIPID METABOLISM
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Keywords
Centella asiatica, Epilepsy, Pentylenetetrazole, Lipids, Rat muscles.
Abstract
The aim of this study is to investigate the anticonvulsant effect of aqueous extract of Centella asiatica (CA) in functionally different muscles with reference to lipid metabolism during pentylenetetrazole (PTZ) induced epilepsy and also during pre-treatment with aqueous extract of CA. Epilepsy is a convulsive episode and is the most frequent neurodegenerative disorder affecting about 50 million people world-wide. Lipid profiles are important components of the neurochemical environment in the muscles of rat. They serve several functions in the biological systems such as structural components of the membranes, storage and transport forms of metabolic fuel, protective coating on the surface concerned in cell recognition, species specifity and tissue immunity. The rats were divided into 4 groups having 6 in each group: (1) Control group received saline, (2) PTZ-induced epileptic group (60 mg/Kg, i.p.), (3) Epileptic group pretreated with aqueous extract (AE) and (4) Epileptic group pretreated with diazepam 2mg/kg body weight. PTZ-induced epilepsy increased the Lipid peeroxidation and decreased the Phospholipids, Total Cholesterol and Triglycerides in all the muscles (White vastus, Red vastus, Soleus and Gastrocnemius). Pre-treatment with aqueous extract (AE) showed a conspicuous recovery. From the results, it is acknowledged that the bioactive factors present in aqueous extract of CA offered protection against PTZ-induced alterations occurred in different muscles.
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How To Cite (APA)
Dr. KANCHI SIVA PRASAD & Dr. ERLA KOMALI (March-2024). ANTI EPILEPTIC PROPERTIES OF CENTELLA ASIATICA AGAINST PENTYLENETETRAZOLE INDUCED EPILEPSY IN RATS WITH REFERENCE TO LIPID METABOLISM. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(3), g125-g134. https://ijnrd.org/papers/IJNRD2403617.pdf
Issue
Volume 9 Issue 3, March-2024
Pages : g125-g134
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Paper Reg. ID: IJNRD_216883
Published Paper Id: IJNRD2403617
Downloads: 000122031
Research Area: Life SciencesÂ
Author Type: Indian Author
Country: GUDUR, Andhra Pradesh, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2403617.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2403617
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