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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | ANTI EPILEPTIC PROPERTIES OF CENTELLA ASIATICA AGAINST PENTYLENETETRAZOLE INDUCED EPILEPSY IN RATS WITH REFERENCE TO LIPID METABOLISM |
| Authors Name: | Dr. KANCHI SIVA PRASAD , Dr. ERLA KOMALI |
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IJNRD_216883
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| Published Paper Id: | IJNRD2403617 |
| Published In: | Volume 9 Issue 3, March-2024 |
| DOI: | |
| Abstract: | The aim of this study is to investigate the anticonvulsant effect of aqueous extract of Centella asiatica (CA) in functionally different muscles with reference to lipid metabolism during pentylenetetrazole (PTZ) induced epilepsy and also during pre-treatment with aqueous extract of CA. Epilepsy is a convulsive episode and is the most frequent neurodegenerative disorder affecting about 50 million people world-wide. Lipid profiles are important components of the neurochemical environment in the muscles of rat. They serve several functions in the biological systems such as structural components of the membranes, storage and transport forms of metabolic fuel, protective coating on the surface concerned in cell recognition, species specifity and tissue immunity. The rats were divided into 4 groups having 6 in each group: (1) Control group received saline, (2) PTZ-induced epileptic group (60 mg/Kg, i.p.), (3) Epileptic group pretreated with aqueous extract (AE) and (4) Epileptic group pretreated with diazepam 2mg/kg body weight. PTZ-induced epilepsy increased the Lipid peeroxidation and decreased the Phospholipids, Total Cholesterol and Triglycerides in all the muscles (White vastus, Red vastus, Soleus and Gastrocnemius). Pre-treatment with aqueous extract (AE) showed a conspicuous recovery. From the results, it is acknowledged that the bioactive factors present in aqueous extract of CA offered protection against PTZ-induced alterations occurred in different muscles. |
| Keywords: | Centella asiatica, Epilepsy, Pentylenetetrazole, Lipids, Rat muscles. |
| Cite Article: | "ANTI EPILEPTIC PROPERTIES OF CENTELLA ASIATICA AGAINST PENTYLENETETRAZOLE INDUCED EPILEPSY IN RATS WITH REFERENCE TO LIPID METABOLISM", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.9, Issue 3, page no.g125-g134, March-2024, Available :http://www.ijnrd.org/papers/IJNRD2403617.pdf |
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2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2403617 Registration ID: 216883 Published In: Volume 9 Issue 3, March-2024 DOI (Digital Object Identifier): Page No: g125-g134 Country: GUDUR, Andhra Pradesh, India Research Area: Life Sciences Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2403617 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2403617 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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