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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | Development and characterization of novel matrix dispersion system based on phospholipid complex for improving oral delivery of ferulic acid |
| Authors Name: | V.R.Gawade , Dr.V.R.Pawar , Dr.R.D.Mapari , H.S.Lahane , G.U.Chavan |
| Download E-Certificate: | Download |
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IJNRD_216582
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| Published Paper Id: | IJNRD2403505 |
| Published In: | Volume 9 Issue 3, March-2024 |
| DOI: | |
| Abstract: | Phospholipid complex is one of the most successful approaches for enhancing oral bioavailability of poorly absorbed plant constituents. But the sticky property of phospholipids results in an unsatisfactory dissolution of drugs. In this study, a matrix dispersion of ferulic acid based on phospholipid complex (MD-FAPLC) was prepared by a sonocomplex method, in which pentaerythritol was employed for improving the dispersibility of ferulic acid phospholipid complex (FAPLC) and increasing dissolution of ferulic acid. The combination ratio of ferulic acid, phospholipid and pentaerythritol was 1:2:5. The pentaerthritol use as dissolution enhancer and dispersing agent. Differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM) and Fourier Transform Infrared (FTIR) analyzes demonstrated that ferulic acid was fully transformed to an amorphous state in MD-FAPC and phospholipid complex formed. The water-solubility and n-octanol solubility of ferulic acid in MD-FAPC significantly increased compared with those of pure FA. Compared with FA and FAPC, the cumulative dissolution of MD-FAPLC at 120 min. the dissolution of MD-FAPC increase compare to pure FA. The novel MD-FAPLC significantly enhanced the oral bioavailability of ferulic acid by improving the dissolution and permeability of ferulic acid without destroying the complexation state of ferulic acid and phospholipids. |
| Keywords: | Ferulic acid, LIPOID® S 100, pentaerythritol. Phospholipid complex |
| Cite Article: | "Development and characterization of novel matrix dispersion system based on phospholipid complex for improving oral delivery of ferulic acid", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.9, Issue 3, page no.f34-f50, March-2024, Available :http://www.ijnrd.org/papers/IJNRD2403505.pdf |
| Downloads: | 00061 |
| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2403505 Registration ID: 216582 Published In: Volume 9 Issue 3, March-2024 DOI (Digital Object Identifier): Page No: f34-f50 Country: Buldhana , maharastra , India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2403505 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2403505 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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