Paper Title
Development and characterization of novel matrix dispersion system based on phospholipid complex for improving oral delivery of ferulic acid
Article Identifiers
: Authors
Keywords
Ferulic acid, LIPOID® S 100, pentaerythritol. Phospholipid complex
Abstract
Phospholipid complex is one of the most successful approaches for enhancing oral bioavailability of poorly absorbed plant constituents. But the sticky property of phospholipids results in an unsatisfactory dissolution of drugs. In this study, a matrix dispersion of ferulic acid based on phospholipid complex (MD-FAPLC) was prepared by a sonocomplex method, in which pentaerythritol was employed for improving the dispersibility of ferulic acid phospholipid complex (FAPLC) and increasing dissolution of ferulic acid. The combination ratio of ferulic acid, phospholipid and pentaerythritol was 1:2:5. The pentaerthritol use as dissolution enhancer and dispersing agent. Differential scanning calorimetry (DSC), X-ray diffraction (XRD), scanning electron microscopy (SEM) and Fourier Transform Infrared (FTIR) analyzes demonstrated that ferulic acid was fully transformed to an amorphous state in MD-FAPC and phospholipid complex formed. The water-solubility and n-octanol solubility of ferulic acid in MD-FAPC significantly increased compared with those of pure FA. Compared with FA and FAPC, the cumulative dissolution of MD-FAPLC at 120 min. the dissolution of MD-FAPC increase compare to pure FA. The novel MD-FAPLC significantly enhanced the oral bioavailability of ferulic acid by improving the dissolution and permeability of ferulic acid without destroying the complexation state of ferulic acid and phospholipids.
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How To Cite (APA)
V.R.Gawade , Dr.V.R.Pawar , Dr.R.D.Mapari , H.S.Lahane , & G.U.Chavan (March-2024). Development and characterization of novel matrix dispersion system based on phospholipid complex for improving oral delivery of ferulic acid. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(3), f34-f50. https://ijnrd.org/papers/IJNRD2403505.pdf
Issue
Volume 9 Issue 3, March-2024
Pages : f34-f50
Other Publication Details
Paper Reg. ID: IJNRD_216582
Published Paper Id: IJNRD2403505
Downloads: 000122006
Research Area: Pharmacy
Author Type: Indian Author
Country: Buldhana , maharastra , India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2403505.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2403505
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