Navigating Warfarin's Pharmacological Maze: A Review Of Drug-Drug Interactions

Navigating Warfarin's Pharmacological Maze: A Review Of Drug-Drug Interactions

Registration ID: IJNRD_216355

Published ID: IJNRD2403478

DOI: Click Here to Get

Vishal K R , Syed Muhammad

Warfarin, Anticoagulation therapy, Drug interactions, Pharmacokinetics, Pharmacodynamics, Cytochrome P450 enzymes, Vitamin K antagonists, INR (International Normalized Ratio), Clinical implications, Adverse effects.

Warfarin, a commonly prescribed anticoagulant, has over 250 known drug interactions that can significantly impact its therapeutic efficacy and safety. These interactions can occur with various medications, dietary supplements, and food items, with approximately 120 drugs or foods interacting with warfarin. The concurrent use of potentially interacting drugs during warfarin therapy is a common practice, with about half of patients receiving warfarin being prescribed concomitant drugs with high potential for interactions. These interactions can interfere with the maintenance of the International Normalized Ratio (INR) within the therapeutic range, leading to an increased risk of bleeding events. Studies have shown that the risk of serious bleeding in patients treated with warfarin is significantly higher when they are using potentially interacting drugs, compared to those on warfarin alone. The influence of drug-drug interactions on the risk of cerebral hemorrhage induced by warfarin has also been investigated. In conclusion, warfarin drug interactions are of great clinical importance, as a large number of patients who take concomitant medications that can increase the INR or the risk of bleeding are at risk.

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"Navigating Warfarin's Pharmacological Maze: A Review Of Drug-Drug Interactions ", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.9, Issue 3, page no.e633-e639, March-2024, Available :https://ijnrd.org/papers/IJNRD2403478.pdf

Volume 9 Issue 3, March-2024

Pages : e633-e639

Paper Reg. ID: IJNRD_216355

Published Paper Id: IJNRD2403478

Downloads: 000121239

Research Area: Pharmacy

Country: Bengaluru, Karnataka, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2403478.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2403478

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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