Paper Title
UNRAVELING HPLC MYSTERIES: A COMPREHENSIVE TROUBLESHOOTING GUIDE
Article Identifiers
Authors
Vishwas Jibkate , Sanket Kurumkar , Sagar Raut , Nishant Awandekar , Milind Umekar
Keywords
HPLC, Detector, Sample Preparation, Troubleshooting
Abstract
ABSTRACT: “Unraveling HPLC Mysteries: A Comprehensive Troubleshooting Guide” delves into the intricacies of High-Performance Liquid Chromatography (HPLC) to offer a thorough roadmap for resolving common challenges chromatography encounters. HPLC is a cornerstone technique across diverse scientific domains, yet its effectiveness can be compromised by issues ranging from peak broadening to baseline instability. This review paper meticulously dissects these challenges, presenting an exhaustive array of potential sources and corresponding remedies. It navigates through critical aspects such as column selection, mobile phase optimization, sample preparation techniques, and instrument maintenance protocols. By comprehensively addressing each facet of HPLC troubleshooting, this guide empowers chromatographers to diagnose and rectify problems confidently and precisely. Additionally, it explores advanced strategies for enhancing method robustness and ensuring reproducibility, bolstering the reliability of chromatographic analyses. Through a synthesis of theoretical insights and practical wisdom garnered from real-world experiences, this guide illuminates the complexities of HPLC. It equips practitioners with the requisite expertise to overcome obstacles effectively. By demystifying the intricacies of HPLC troubleshooting, this paper serves as an invaluable resource for researchers, analysts, and students alike, fostering a deeper understanding of chromatographic principles and facilitating advancements in analytical chemistry and related fields.
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How To Cite (APA)
Vishwas Jibkate, Sanket Kurumkar, Sagar Raut, Nishant Awandekar, & Milind Umekar (March-2024). UNRAVELING HPLC MYSTERIES: A COMPREHENSIVE TROUBLESHOOTING GUIDE. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(3), e271-e284. https://ijnrd.org/papers/IJNRD2403434.pdf
Issue
Volume 9 Issue 3, March-2024
Pages : e271-e284
Other Publication Details
Paper Reg. ID: IJNRD_216044
Published Paper Id: IJNRD2403434
Downloads: 000121993
Research Area: Pharmacy
Country: Nagpur, Maharashtra , India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2403434.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2403434
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Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)
ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016
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This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition
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