PAMAM G4 Dendrimers & Vitamin D Nano Complex for delivery of Doxorubicin

Registration ID: IJNRD_215840

Published ID: IJNRD2403315

: http://doi.one/10.1729/Journal.38481

Pragati Singh, Nancy Tiwari, Ranveer Singh, Priyanka Singh

Dendrimer, Doxorubicin, Vitamin D, Cancer therapy, Drug release kinetics, Targeted delivery, In vivo efficacy.

In cancer treatment, efficient drug delivery systems are imperative to enhance therapeutic efficacy while minimizing systemic toxicity. This study explores the potential of a novel nano-complex composed of PAMAM G4 dendrimers and vitamin D for the targeted delivery of doxorubicin (DOX), a widely used chemotherapeutic agent. The synthesis and characterization of the nano-complex were meticulously conducted, elucidating its physicochemical properties and structural integrity.The encapsulation of DOX within the nano-complex was optimized, ensuring high drug loading efficiency and sustained release kinetics. Moreover, the synergistic effects of vitamin D were harnessed to augment the anticancer activity of DOX while mitigating its adverse effects on normal tissues. Cellular uptake studies revealed enhanced internalization of the nano-complex in cancer cells, facilitated by receptor-mediated endocytosis mechanisms.In vitro studies demonstrated the superior cytotoxicity of the DOX-loaded nano-complex compared to free DOX, attributed to its targeted delivery and intracellular release. Furthermore, the nano-complex exhibited favorable biocompatibility profiles, minimizing off-target effects on healthy cells. In vivo efficacy assessments using xenograft tumor models corroborated the enhanced therapeutic outcomes of the nano-complex, showcasing significant tumor growth inhibition and prolonged survival rates compared to conventional DOX formulations. Pharmacokinetic studies indicated improved circulation half-life and bioavailability of DOX when delivered via the nano-complex.

Published Paper   E-Certificate

Pragati Singh, Nancy Tiwari, Ranveer Singh, & Priyanka Singh (March-2024). PAMAM G4 Dendrimers & Vitamin D Nano Complex for delivery of Doxorubicin. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(3), d102-d113. http://doi.one/10.1729/Journal.38481

Volume 9 Issue 3, March-2024

Pages : d102-d113

Paper Reg. ID: IJNRD_215840

Published Paper Id: IJNRD2403315

Downloads: 000122257

Research Area: Pharmacy

Author Type: Indian Author

Country: Lucknow, Uttar Pradesh, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2403315.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2403315

Crossref DOI: http://doi.one/10.1729/Journal.38481

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

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