PAMAM G4 Dendrimers & Vitamin D Nano Complex for delivery of Doxorubicin

PAMAM G4 Dendrimers & Vitamin D Nano Complex for delivery of Doxorubicin

Registration ID: IJNRD_215840

Published ID: IJNRD2403315

DOI: http://doi.one/10.1729/Journal.38481

Pragati Singh , Nancy Tiwari , Ranveer Singh , Priyanka Singh

Dendrimer, Doxorubicin, Vitamin D, Cancer therapy, Drug release kinetics, Targeted delivery, In vivo efficacy.

In cancer treatment, efficient drug delivery systems are imperative to enhance therapeutic efficacy while minimizing systemic toxicity. This study explores the potential of a novel nano-complex composed of PAMAM G4 dendrimers and vitamin D for the targeted delivery of doxorubicin (DOX), a widely used chemotherapeutic agent. The synthesis and characterization of the nano-complex were meticulously conducted, elucidating its physicochemical properties and structural integrity.The encapsulation of DOX within the nano-complex was optimized, ensuring high drug loading efficiency and sustained release kinetics. Moreover, the synergistic effects of vitamin D were harnessed to augment the anticancer activity of DOX while mitigating its adverse effects on normal tissues. Cellular uptake studies revealed enhanced internalization of the nano-complex in cancer cells, facilitated by receptor-mediated endocytosis mechanisms.In vitro studies demonstrated the superior cytotoxicity of the DOX-loaded nano-complex compared to free DOX, attributed to its targeted delivery and intracellular release. Furthermore, the nano-complex exhibited favorable biocompatibility profiles, minimizing off-target effects on healthy cells. In vivo efficacy assessments using xenograft tumor models corroborated the enhanced therapeutic outcomes of the nano-complex, showcasing significant tumor growth inhibition and prolonged survival rates compared to conventional DOX formulations. Pharmacokinetic studies indicated improved circulation half-life and bioavailability of DOX when delivered via the nano-complex.

Published Paper   E-Certificate

"PAMAM G4 Dendrimers & Vitamin D Nano Complex for delivery of Doxorubicin", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.9, Issue 3, page no.d102-d113, March-2024, Available :https://ijnrd.org/papers/IJNRD2403315.pdf

Volume 9 Issue 3, March-2024

Pages : d102-d113

Paper Reg. ID: IJNRD_215840

Published Paper Id: IJNRD2403315

Downloads: 000121153

Research Area: Pharmacy

Country: Lucknow, Uttar Pradesh, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2403315.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2403315

DOI: http://doi.one/10.1729/Journal.38481

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJNRD (IJ Publication) Janvi Wave

This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition

Call For Paper - Volume 10 | Issue 8 | August 2025

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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (IJNRD) aims to explore advances in research pertaining to applied, theoretical and experimental Technological studies. The goal is to promote scientific information interchange between researchers, developers, engineers, students, and practitioners working in and around the world. IJNRD will provide an opportunity for practitioners and educators of engineering field to exchange research evidence, models of best practice and innovative ideas.

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