Paper Title
Ciprofloxacin ocuserts: Design, Formulation and Evaluation
Article Identifiers
Authors
Prajwal D. Shrirao , Navnath S. Rathod , Ajwita S. Kale , Nikita P. Aware , Ram S. Ghotkar
Keywords
Ciprofloxacin, ocuserts, bovine cornea, Franz diffusion cell, keratoconjunctivitis
Abstract
The main aim of the present study is to formulate an effective ocusert of Ciprofloxacin (an anti-biotic drug), which can produce a better ocular therapy against ocular bacterial infections. Conjunctivitis, keratitis, and keratoconjunctivitis are just a few examples of the eye infections that can be treated with ciprofloxacin hydrochloride, a fluoroquinolone antibiotic. By using different polymers in various ratios and combinations, including Poly Vinyl Alcohol (PVA), Hydroxy Propyl Methyl Cellulose (HPMC), Methyl Cellulose (MC), and Hydroxy Ethyl Cellulose (HEC), Ciprofloxacin Hydrochloride Ocuserts were made with the goal of extending the contact time, achieving sustained release, reducing the frequency of administration, improving patient compliance, and enhancing therapeutic efficacy. Here, I'm using hydroxyl methyl cellulose, which is 15cps grade, low viscosity methyl cellulose, and warm water soluble poly vinyl alcohol. The prepared ocuserts' physico-chemical properties were assessed for sterility testing, ocular irritation studies, moisture absorption, moisture loss, thickness, weight variation, folding endurance, and surface pH. Using a bovine cornea (semi permeable membrane) Franz diffusion cell, the in vitro drug release was investigated, and the maximum absorbance at 274 nm was checked. A zero order release formulation FB2 is sterilized by exposing UV radiation and subjected to In vivo studies. Ocular toxicity was also carried out for the formulation FB2. IR spectral observation show there is no interaction of drug with polymer which indicates the intactness of drug in formulation.
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How To Cite (APA)
Prajwal D. Shrirao, Navnath S. Rathod, Ajwita S. Kale, Nikita P. Aware, & Ram S. Ghotkar (March-2024). Ciprofloxacin ocuserts: Design, Formulation and Evaluation. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(3), c313-c316. https://ijnrd.org/papers/IJNRD2403242.pdf
Issue
Volume 9 Issue 3, March-2024
Pages : c313-c316
Other Publication Details
Paper Reg. ID: IJNRD_215311
Published Paper Id: IJNRD2403242
Downloads: 000122002
Research Area: Pharmacy
Country: Washim, Maharashtra, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2403242.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2403242
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Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)
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This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition
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