Development and Evaluation of Fast Dissolving Tablets of Diltiazem Hydrochloride

Registration ID: IJNRD_215185

Published ID: IJNRD2403174

DOI: Click Here to Get

Pramod Kharel , Sujan Neupane , Jaya Bahadur Ghale

Diltiazem Hydrochloride, Fast Dissolving Tablets, Superdisintegrants, Direct Compression Technique, Combination

This study has been carried out with a concept of formulating the fast dissolving tablets of Diltiazem Hydrochloride using various superdisintegrants. To create the dosage form, direct compression technique was used. A total for nine formulations were developed. The combination of synthetic (2-6%) and natural superdisintegrant (2-8%) was incorporated in all the formulations. All the formulations were evaluated for precompression and post compression evaluation parameters. From the observation, it was found that all the formulations were disintegrated within the time range of 27 - 64 seconds. All the prepared formulations complied with the Pharmacopoeial standard requirements of the drug contents. The optimized formulation F6 gave the best results in disintegration time and dissolution studies as compared to other created formulations. The research concluded that the nature of the superdisintegrants influenced the rate of disintegration and drug release rate. From the study, it was assumed that combination of superdisintegrants in certain amount or ratio can enhance the disintegration time for increasing patient compliance.

Published Paper   E-Certificate

Pramod Kharel, Sujan Neupane, & Jaya Bahadur Ghale (March-2024). Development and Evaluation of Fast Dissolving Tablets of Diltiazem Hydrochloride. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(3), b661-b666. https://ijnrd.org/papers/IJNRD2403174.pdf

Volume 9 Issue 3, March-2024

Pages : b661-b666

Paper Reg. ID: IJNRD_215185

Published Paper Id: IJNRD2403174

Downloads: 000121996

Research Area: Pharmacy

Country: Kathmandu, Bagmati, Nepal

Published Paper PDF: https://ijnrd.org/papers/IJNRD2403174.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2403174

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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