Assessing the wound healing effects of Erythrina abyssinica crude aqueous stem bark extract on mechanically induced wounds in wistar rats

Assessing the wound healing effects of Erythrina abyssinica crude aqueous stem bark extract on mechanically induced wounds in wistar rats

Registration ID: IJNRD_212733

Published ID: IJNRD2403163

DOI: Click Here to Get

MWOROZI PETER , KAIZA ALLAN , NEEZA TIMOTHY , NABITANDIKWA CATHERINE , KAYIMA RONALD

Wounds, Herbal medicine, Erythrina abyssinica, Healing, Wistar rats

Wounds tend to affect a large proportion of the population both in developing and developed countries. They can result from accidents both at work and home but most commonly road accidents contribute a large percentage of road accidents. Wounds can impact on the victim’s social life and as well as reducing the productivity of the affected individuals, hence reducing the work output. However, little attention is always given to wounds and their impact in society. Wounds can be open or closed depending on the kind and extent of injury. Therefore the above study sought to find a cheaper and readily available alternative to wound healing especially for the local communities who may find it hard to access or even afford modern alternatives for wound management. In this study, the aqueous stem bark extract of Erythrina abyssinica was used for phytochemical analysis, assessing the wound healing effects and antibacterial properties. The wounds were induced by cutting off a circular part of full thickness from the skin on the dorsal lateral region of each rat by using a sterile surgical blade and the diameter of each wound was measured using a Vanier caliper. The extract and the standard drug for wounds (povidone iodine ointment) were applied topically on the wounds for 9 days and the percentage wound contraction was determined by measuring with a vanier caliper. A negative control of the animals which were induced with wounds but received no intervention was also used for comparison with the results from the standard control. The antibacterial effects of the extract against S. aureus and E. coli was also determined on the same wounds using the same aqueous extract. The results showed that the percentage wound contraction achieved for Erythrina abyssinica extract was 75.5±2.2%, 48.6±6.0% for Povidone iodine and 29.4±2.6% in the untreated wounds. For in vivo antimicrobial activity, Povidone showed higher activity than Erythrina abyssinica crude aqueous extract. It was therefore concluded that the aqueous crude extract of Erythrina abyssinica was better than the standard drug on wound healing but for antimicrobial effects, the standard drug for wound healing (Povidone) showed better results than the extract. Therefore in conclusion, povidone and Erythrina abyssinica, extract can be used concomitantly for wound healing since most of the wounds tend to be septic and infected by bacteria. The combination can provide additive effects on wounds resulting in rapid wound healing rates.

Published Paper   E-Certificate

"Assessing the wound healing effects of Erythrina abyssinica crude aqueous stem bark extract on mechanically induced wounds in wistar rats", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.9, Issue 3, page no.b580-b592, March-2024, Available :https://ijnrd.org/papers/IJNRD2403163.pdf

Volume 9 Issue 3, March-2024

Pages : b580-b592

Paper Reg. ID: IJNRD_212733

Published Paper Id: IJNRD2403163

Downloads: 000121204

Research Area: Pharmacy

Country: Sheema, Sheema municipaly , Uganda

Published Paper PDF: https://ijnrd.org/papers/IJNRD2403163.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2403163

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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