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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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Volume 9 | Issue 5
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| Paper Title: | Design and Optimization of Donepezil HCl Orodispersible Tablets |
| Authors Name: | Anand Kumar Y , Jalal Basha |
| Download E-Certificate: | Download |
| Author Reg. ID: |
IJNRD_214185
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| Published Paper Id: | IJNRD2403071 |
| Published In: | Volume 9 Issue 3, March-2024 |
| DOI: | |
| Abstract: | Donepezil HCl (DP) is an acetyl cholinesterase inhibitor used for the treatment of behavioural and cognitive effect of Alzheimer’s disease and other type of dementia. The DP-orodispersible tablets were made using direct compression method and mixture of superdisintegrant crospovidone (CP) and croscarmellose sodium (CCS) chosen through central composite design (CCD). The 23 factorial designs with three responses viz., dispersion time, disintegration time and t50. The precompression results show desirable compression properties and FTIR studies no interaction between the DP and added excipients. The eleven trials of tablets were made and evaluated their response data, further numerical optimization was done through point prediction method using Design expert software Trial V13 to generate optimized formula. The optimized formula was made into tablets, evaluated and validated through statistical methods. The overall results conclude that design of experiments studies can be conveniently applied for optimization of DP loaded orodispersible tablets. |
| Keywords: | Donepezil HCl, Crospovidone, Croscarmellose sodium, Central Composite Design, Design of experiments |
| Cite Article: | "Design and Optimization of Donepezil HCl Orodispersible Tablets", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.9, Issue 3, page no.a652-a662, March-2024, Available :http://www.ijnrd.org/papers/IJNRD2403071.pdf |
| Downloads: | 00056 |
| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2403071 Registration ID: 214185 Published In: Volume 9 Issue 3, March-2024 DOI (Digital Object Identifier): Page No: a652-a662 Country: RAICHUR, KARNATAKA, India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2403071 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2403071 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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