A SINGLE BLIND CLINICAL TRIAL TO EVALUATE THE SAFETY AND EFFICACY OF COMPOUND UNANI FORMULATION IN MANAGEMENT OF DAUS' SADAF (PSORIASIS)

Registration ID: IJNRD_214319

Published ID: IJNRD2402247

DOI: Click Here to Get

DR. SYED SOFIAN AHMED , DR. MOHAMMED AHSAN FAROQUI , DR. ABDUL LATEEF SIDDIQUI

Key words:- Koebner phenomenon, Auspitz’s sign, Quath-e-Muddabir-e-Badan, Sitta Zarooria.

ABSTRACT Background and Objective: Daus ’Sadaf / Taqashur-e-jild, Psoriasis is one the common diseases of the skin, It is characterized by having sharply demarcated scaly red, coin-sized skin lesions most often on the elbows, knees, scalp, hands and feet. Symptoms include itching, irritation, stinging and pain. Signs to diagnose psoriasis are Koebner phenomenon and Auspitz’s sign, there are two key factors which play a important role in Aetiology of psoriasis, 1. Autoimmune: - Naïve t cells, il12 & il23, 2. Genetic factors: - family history found Up to 30%. However, the Daus ’Sadaf commonly developed for those who has loosed their body immunity or Quath-e-Muddabir-e-Badan (Defensive Mechanism) due to abnormal maintenance of "Sitta Zarooria" many caused alternate the Tabiyath (immunity) and abnormal changes will take place in the humorous and temperament. In Unani concept their might be accumulation of abnormal Sauda and Safra Mutahirqa (Jala huwa safra) into the skin, Hence the objective of the study is to Relief nature of the disease through Unani medicine. Methods: - The study was designed as A Single Blind clinical trail with a sample size 40 patients  Joshanda:-21 days Beeq-e-azkhar, Beeq-e- badiyan, Beeq-e-kibr, Beeq-e-karafs, Beeq-e-Kasni, Charaita, Shahitra, Aftimoon, Bisfaij, each 5 grams (OD Dose Before meals 21 days) • Musafiyat:-30 days 1. Qurs-e-sartaan kafoori, one tab BD (after food) 2. Arq-e-murakab musafi khoon, 60ml BD (after food) • Zimad Drugs (Local application): During whole duration of treatment. Ashaq 5 grams, Muqil-e-arzaq 5 grams, Zarvand mudharij 5 grams, Roghan-e-gul 20 ml, Moom-e-zard 20 grams Apply Zimad for a period of (51) days and response of treatment observed, First follow up after using 21 days joshanda (decoction) and then follow up for every 15 days and noted in the case sheets. Similarly, the treatment and response of the lesions measured by PASI Score and Data Analyzed statically. Result: - In this present clinical study of psoriasis, the maximum response out of (40) cases, (24) patients i.e. 60% patients got good response, the satisfactory patients were (10) i.e. 25% and poor response patients were (6) i.e. 15%. P value is <0.0001*. Interpretation and Conclusion: - The study revealed that usage of this Unani medicine got good response in decreasing the sign and symptoms of psoriasis like redness, thickness, itching, and scales. No clinically significant side effects were observed in this study; these results conclude that the drugs used in this study are easily available, safe and effective. Keywords: - Koebner phenomenon, Auspitz’s sign, Quath-e-Muddabir-e-Badan, Sitta Zarooria.

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DR. SYED SOFIAN AHMED , DR. MOHAMMED AHSAN FAROQUI , & DR. ABDUL LATEEF SIDDIQUI (February-2024). A SINGLE BLIND CLINICAL TRIAL TO EVALUATE THE SAFETY AND EFFICACY OF COMPOUND UNANI FORMULATION IN MANAGEMENT OF DAUS' SADAF (PSORIASIS). INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(2), c399-c417. https://ijnrd.org/papers/IJNRD2402247.pdf

Volume 9 Issue 2, February-2024

Pages : c399-c417

Paper Reg. ID: IJNRD_214319

Published Paper Id: IJNRD2402247

Downloads: 000121981

Research Area: Medical Science

Country: HYDERABAD, Telangana, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2402247.pdf

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Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

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