A Review on Mucoadhesive Tablets by Anti-Ulcer Drug Esomeprazole

A Review on Mucoadhesive Tablets by Anti-Ulcer Drug Esomeprazole

Registration ID: IJNRD_213275

Published ID: IJNRD2401334

DOI: Click Here to Get

R. Shireesh Kiran , E. Bunny priya

Key words: Esomeprazole, Chitosan, HPMC K100, Carbopol p934and buccal tablets.

Esomeprazole is a medication used in the treatment of gastroesophageal reflux disease (GERD), peptic ulcer disease, and Zollinger–Ellison syndrome. It is also used to prevent upper gastrointestinal bleeding in people who are at high risk. The Mucoadhesive buccal tablets were prepared by direct compression method using Chitosan, HPMC K100 and Carbopol p934 as mucoadhesive polymer. The compatibility studies of drug and excipients were performed by FT-IR spectroscopy. After examining the flow properties of the powder blends the results are found to be within prescribed limits and indicated good flowing property, hence it was subjected to tablet compression. The tablets were evaluated for post compression parameters like weight variation, hardness, thickness, friability, drug content uniformity, Surface pH, in-vitro studies like drug release. Formulation (F4) containing HPMC K100 in the ratio of (1:1) showed maximum drug release of 99.54% in 8 hrs. The drug content of shown highest of 99.61 %, Surface pH was found to be 6.05. All the evaluation parameters given the positive results and comply with the standards. The results indicate that the mucoadhesive buccal tablets of Esomeprazole may be good choice to bypass the extensive hepatic first pass metabolism with an improvement in the bioavailability of Esomeprazole through buccal mucosa.

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"A Review on Mucoadhesive Tablets by Anti-Ulcer Drug Esomeprazole", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.9, Issue 1, page no.d249-d255, January-2024, Available :https://ijnrd.org/papers/IJNRD2401334.pdf

Volume 9 Issue 1, January-2024

Pages : d249-d255

Paper Reg. ID: IJNRD_213275

Published Paper Id: IJNRD2401334

Downloads: 000121198

Research Area: Pharmacy

Country: HYDERABAD, TELANGANA, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2401334.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2401334

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJNRD (IJ Publication) Janvi Wave

This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition

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