INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016
Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI)
Esomeprazole is a medication used in the treatment of gastroesophageal reflux disease
(GERD), peptic ulcer disease, and Zollinger–Ellison syndrome. It is also used to prevent
upper gastrointestinal bleeding in people who are at high risk. The Mucoadhesive buccal
tablets were prepared by direct compression method using Chitosan, HPMC K100 and
Carbopol p934 as mucoadhesive polymer. The compatibility studies of drug and excipients
were performed by FT-IR spectroscopy. After examining the flow properties of the powder
blends the results are found to be within prescribed limits and indicated good flowing
property, hence it was subjected to tablet compression. The tablets were evaluated for post
compression parameters like weight variation, hardness, thickness, friability, drug content
uniformity, Surface pH, in-vitro studies like drug release. Formulation (F4) containing
HPMC K100 in the ratio of (1:1) showed maximum drug release of 99.54% in 8 hrs. The
drug content of shown highest of 99.61 %, Surface pH was found to be 6.05. All the
evaluation parameters given the positive results and comply with the standards. The results
indicate that the mucoadhesive buccal tablets of Esomeprazole may be good choice to bypass
the extensive hepatic first pass metabolism with an improvement in the bioavailability of
Esomeprazole through buccal mucosa.
"Formulation and Development of Mucoadhesive Tablets by Anti-Ulcer Drug Esomeprazole", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.9, Issue 1, page no.d237-d248, January-2024, Available :http://www.ijnrd.org/papers/IJNRD2401333.pdf
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ISSN:
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
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