Paper Title
FORMULATION, DEVELOPMENT AND EVALUATION OF FAST DESSOLVING TABLET OF LOSARTAN POTASSIUM AND NIFEDIPINE
Article Identifiers
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Keywords
Losartan potassium, nifedipine, super disintegrants, fast dissolving tablets (FDTS).
Abstract
Fast dissolving tablet format designed to allow administration of an oral dose form in the absence of water or fluid intake. The tablets rapidly dissolve or disintegrate in the saliva. Formulation research is oriented towards increasing the efficacy of existing drug molecule thought novel concepts of drug delivery. Losartan potassium and Nifedipine widely used as an antihypertensive drug. The aim of this study was to improve the solubility of Losartan potassium and nifedipine and increasing its disintegration time by formulation of fast dissolving tablets by direct compression method and various ratios of cross povidone (CP) cross carmellose sodium (CCS) sodium starch glycolate (SSG) as Superdisintegrants. The tablet pre compression parameter e.g. angle of repose, bulk density, tapped density, carr’s compressibility index and hausner’s ratio and post compression parameter like drug content uniformity, hardness, wetting time, friability, thickness, disintegration time, were evaluated for each formulation and found satisfactory.
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How To Cite (APA)
SONALI PATIDAR & Shweta Sitole (January-2024). FORMULATION, DEVELOPMENT AND EVALUATION OF FAST DESSOLVING TABLET OF LOSARTAN POTASSIUM AND NIFEDIPINE. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(1), d157-d166. https://ijnrd.org/papers/IJNRD2401322.pdf
Issue
Volume 9 Issue 1, January-2024
Pages : d157-d166
Other Publication Details
Paper Reg. ID: IJNRD_212606
Published Paper Id: IJNRD2401322
Downloads: 000122254
Research Area: Pharmacy
Author Type: Indian Author
Country: KHARGONE, MP, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2401322.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2401322
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