FORMULATION, DEVELOPMENT AND EVALUATION OF FAST DESSOLVING TABLET OF LOSARTAN POTASSIUM AND NIFEDIPINE

FORMULATION, DEVELOPMENT AND EVALUATION OF FAST DESSOLVING TABLET OF LOSARTAN POTASSIUM AND NIFEDIPINE

Registration ID: IJNRD_212606

Published ID: IJNRD2401322

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SONALI PATIDAR , Shweta Sitole

Losartan potassium, nifedipine, super disintegrants, fast dissolving tablets (FDTS).

Fast dissolving tablet format designed to allow administration of an oral dose form in the absence of water or fluid intake. The tablets rapidly dissolve or disintegrate in the saliva. Formulation research is oriented towards increasing the efficacy of existing drug molecule thought novel concepts of drug delivery. Losartan potassium and Nifedipine widely used as an antihypertensive drug. The aim of this study was to improve the solubility of Losartan potassium and nifedipine and increasing its disintegration time by formulation of fast dissolving tablets by direct compression method and various ratios of cross povidone (CP) cross carmellose sodium (CCS) sodium starch glycolate (SSG) as Superdisintegrants. The tablet pre compression parameter e.g. angle of repose, bulk density, tapped density, carr’s compressibility index and hausner’s ratio and post compression parameter like drug content uniformity, hardness, wetting time, friability, thickness, disintegration time, were evaluated for each formulation and found satisfactory.

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"FORMULATION, DEVELOPMENT AND EVALUATION OF FAST DESSOLVING TABLET OF LOSARTAN POTASSIUM AND NIFEDIPINE", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.9, Issue 1, page no.d157-d166, January-2024, Available :https://ijnrd.org/papers/IJNRD2401322.pdf

Volume 9 Issue 1, January-2024

Pages : d157-d166

Paper Reg. ID: IJNRD_212606

Published Paper Id: IJNRD2401322

Downloads: 000121166

Research Area: Pharmacy

Country: KHARGONE, MP, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2401322.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2401322

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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