INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016
Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI)
Thyroxine had crystallised in 1914. Thyroxine was first synthesised as an acid in 1927, which restricted its oral absorption. In 1949, a sodium form of thyroxine was finally made available. After that, these artificial preparations were made available for medical application. Before 1970, LT4 and LT3 were typically replaced with extracts and combination therapy. However, endogenous production of T3 from LT4 in thyreotic patients was observed by peripheral deiodinase-mediated T4 to T3 conversion. For the majority of the 20th century, the market was controlled by natural thyroid preparations, such as thyroglobulin, desiccated thyroid, or thyroid extract, which include both triiodothyronine (T3) and thyroxine (T4). These preparations were the first pharmacologic treatments accessible. Although L-thyroxine monotherapy has been successful, some authors have questioned its effectiveness due to the fact that 10% to 15% of patients experience residual symptoms of hypothyroidism, which can include neurocognitive impairment.[3] and 15% of patients do not achieve normal serum triiodothyronine (T3) levels.[4]
Keywords:
Toxicity, Levothyroxine, Hormone
Cite Article:
"Understanding Adverse Effect And Toxicity of Levothyroxine", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.9, Issue 1, page no.b878-b893, January-2024, Available :http://www.ijnrd.org/papers/IJNRD2401199.pdf
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ISSN:
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
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