Paper Title
“MAGICAL TECHNOLOGY: MS/MS FOR THERAPEUTIC 28 ANTIEPILEPTIC DRUGS MONITORING IN HUMAN.â€
Article Identifiers
Authors
Dr.MItesh A Bhatt , Dr.Akash Shah , Dr.Sandip Shah , Dr.Bhavini Shah , Mrs.Ankita Murnal
Keywords
Antiepileptic; UPLC-MS/MS; human serum
Abstract
The aim of this study was to develop and validate a simple, robust and sensitive ultra performance liquid chromatography tandem mass spectrometry (UPLC–MS/MS) method for the simultaneous analysis of 28 antiepileptic drugs (AEDs) in human serum. Fifty microliters of human serum were extracted using a protein precipitation extraction method and the final extracts were analyzed using reserve chromatography and triple-quadrupole tandem mass spectrometer by multiple reactions monitoring (MRM) mode via Electro spray ionization (ESI). Chromatographic separation was achieved on a JNJ C18 column within 6 min via isocratic elution with an aqueous solution containing 10 mM ammonium acetate and an organic solution containing acetonitrile, at the flow rate of 0.3 mL/min. Method validation consisted of linearity, sensitivity, accuracy and precision, all antiepileptic drugs were detected and quantified within 6 min without endogenous interferences. The correlation coefficient (R2) was >0.99 for all antiepileptic drugs with accuracy ranging from 93 to 107% and precision < 8% for all analytes. No carryover was observed in a blank control injected after the highest standard. The method has been successfully verified using authentic case samples that had previously been quantified using different methods. The assay is suitable for clinical utilization and management of patients on these medications.
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How To Cite (APA)
Dr.MItesh A Bhatt, Dr.Akash Shah, Dr.Sandip Shah, Dr.Bhavini Shah, & Mrs.Ankita Murnal (January-2024). “MAGICAL TECHNOLOGY: MS/MS FOR THERAPEUTIC 28 ANTIEPILEPTIC DRUGS MONITORING IN HUMAN.â€. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(1), b761-b770. https://ijnrd.org/papers/IJNRD2401186.pdf
Issue
Volume 9 Issue 1, January-2024
Pages : b761-b770
Other Publication Details
Paper Reg. ID: IJNRD_212616
Published Paper Id: IJNRD2401186
Downloads: 000121978
Research Area: Life SciencesÂ
Country: Ahmedabad, Gujarat , Ground Floor, Kedar Builiding, , India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2401186.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2401186
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This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition


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