|
|||||||||||||||
|
INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
||||||||||||||
Issue: May 2024
Volume 9 | Issue 5
Review Result and Publication of Paper within : 2-3 days
Click Here For more DetailsFor Authors
Forms / Download
Published Issue Details
Editorial Board
Other IMP Links
Facts & Figure
Impact Factor : 8.76
Issue per Year : 12
Volume Published : 9
Issue Published : 96
Article Submitted :
Article Published :
Total Authors :
Total Reviewer :
Total Countries :
Indexing Partner
Join RMS/Earn 300
Licence
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
|
Published Paper Details
|
|
| Paper Title: | “MAGICAL TECHNOLOGY: MS/MS FOR THERAPEUTIC 28 ANTIEPILEPTIC DRUGS MONITORING IN HUMAN.” |
| Authors Name: | Dr.MItesh A Bhatt , Dr.Akash Shah , Dr.Sandip Shah , Dr.Bhavini Shah , Mrs.Ankita Murnal |
| Download E-Certificate: | Download |
| Author Reg. ID: |
IJNRD_212616
|
| Published Paper Id: | IJNRD2401186 |
| Published In: | Volume 9 Issue 1, January-2024 |
| DOI: | |
| Abstract: | The aim of this study was to develop and validate a simple, robust and sensitive ultra performance liquid chromatography tandem mass spectrometry (UPLC–MS/MS) method for the simultaneous analysis of 28 antiepileptic drugs (AEDs) in human serum. Fifty microliters of human serum were extracted using a protein precipitation extraction method and the final extracts were analyzed using reserve chromatography and triple-quadrupole tandem mass spectrometer by multiple reactions monitoring (MRM) mode via Electro spray ionization (ESI). Chromatographic separation was achieved on a JNJ C18 column within 6 min via isocratic elution with an aqueous solution containing 10 mM ammonium acetate and an organic solution containing acetonitrile, at the flow rate of 0.3 mL/min. Method validation consisted of linearity, sensitivity, accuracy and precision, all antiepileptic drugs were detected and quantified within 6 min without endogenous interferences. The correlation coefficient (R2) was >0.99 for all antiepileptic drugs with accuracy ranging from 93 to 107% and precision < 8% for all analytes. No carryover was observed in a blank control injected after the highest standard. The method has been successfully verified using authentic case samples that had previously been quantified using different methods. The assay is suitable for clinical utilization and management of patients on these medications. |
| Keywords: | Antiepileptic; UPLC-MS/MS; human serum |
| Cite Article: | "“MAGICAL TECHNOLOGY: MS/MS FOR THERAPEUTIC 28 ANTIEPILEPTIC DRUGS MONITORING IN HUMAN.”", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.9, Issue 1, page no.b761-b770, January-2024, Available :http://www.ijnrd.org/papers/IJNRD2401186.pdf |
| Downloads: | 000118759 |
| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
| Publication Details: |
Published Paper ID:IJNRD2401186 Registration ID: 212616 Published In: Volume 9 Issue 1, January-2024 DOI (Digital Object Identifier): Page No: b761-b770 Country: Ahmedabad, Gujarat , Ground Floor, Kedar Builiding, , India Research Area: Life Sciences Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2401186 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2401186 |
| Share Article: |
|
|
Click Here to Download This Article |
|
| Article Preview | |
|
|
|
Major Indexing from www.ijnrd.org
| Semantic Scholar | Microsaoft Academic | ORCID | Zenodo |
| Google Scholar | ResearcherID Thomson Reuters | Mendeley : reference manager | Academia.edu |
| arXiv.org : cornell university library | Research Gate | CiteSeerX | PUBLON |
| DRJI | SSRN | Scribd | DocStoc |
ISSN Details
 |
 |
|
ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
Journal Starting Year (ESTD) : 2016
DOI (A digital object identifier)
Conference
Open Access License Policy
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
Important Details
Social Media
Licence
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
Join RMS/Earn 300
| Copyright © 2024 - All Rights Reserved - IJNRD |
Facebook Twitter Instagram LinkedIn