Paper Title

“MAGICAL TECHNOLOGY: MS/MS FOR THERAPEUTIC 28 ANTIEPILEPTIC DRUGS MONITORING IN HUMAN.”

Article Identifiers

Registration ID: IJNRD_212616

Published ID: IJNRD2401186

DOI: Click Here to Get

Authors

Dr.MItesh A Bhatt , Dr.Akash Shah , Dr.Sandip Shah , Dr.Bhavini Shah , Mrs.Ankita Murnal

Keywords

Antiepileptic; UPLC-MS/MS; human serum

Abstract

The aim of this study was to develop and validate a simple, robust and sensitive ultra performance liquid chromatography tandem mass spectrometry (UPLC–MS/MS) method for the simultaneous analysis of 28 antiepileptic drugs (AEDs) in human serum. Fifty microliters of human serum were extracted using a protein precipitation extraction method and the final extracts were analyzed using reserve chromatography and triple-quadrupole tandem mass spectrometer by multiple reactions monitoring (MRM) mode via Electro spray ionization (ESI). Chromatographic separation was achieved on a JNJ C18 column within 6 min via isocratic elution with an aqueous solution containing 10 mM ammonium acetate and an organic solution containing acetonitrile, at the flow rate of 0.3 mL/min. Method validation consisted of linearity, sensitivity, accuracy and precision, all antiepileptic drugs were detected and quantified within 6 min without endogenous interferences. The correlation coefficient (R2) was >0.99 for all antiepileptic drugs with accuracy ranging from 93 to 107% and precision < 8% for all analytes. No carryover was observed in a blank control injected after the highest standard. The method has been successfully verified using authentic case samples that had previously been quantified using different methods. The assay is suitable for clinical utilization and management of patients on these medications.

How To Cite (APA)

Dr.MItesh A Bhatt, Dr.Akash Shah, Dr.Sandip Shah, Dr.Bhavini Shah, & Mrs.Ankita Murnal (January-2024). “MAGICAL TECHNOLOGY: MS/MS FOR THERAPEUTIC 28 ANTIEPILEPTIC DRUGS MONITORING IN HUMAN.”. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(1), b761-b770. https://ijnrd.org/papers/IJNRD2401186.pdf

Issue

Volume 9 Issue 1, January-2024

Pages : b761-b770

Other Publication Details

Paper Reg. ID: IJNRD_212616

Published Paper Id: IJNRD2401186

Downloads: 000121978

Research Area: Life Sciences 

Country: Ahmedabad, Gujarat , Ground Floor, Kedar Builiding, , India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2401186.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2401186

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Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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Call For Paper - Volume 10 | Issue 10 | October 2025

IJNRD is a Scholarly Open Access, Peer-reviewed, and Refereed Journal with a High Impact Factor of 8.76 (calculated by Google Scholar & Semantic Scholar | AI-Powered Research Tool). It is a Multidisciplinary, Monthly, Low-Cost Journal that follows UGC CARE 2025 Peer-Reviewed Journal Policy norms, Scopus journal standards, and Transparent Peer Review practices to ensure quality and credibility. IJNRD provides indexing in all major databases & metadata repositories, a citation generator, and Digital Object Identifier (DOI) for every published article with full open-access visibility.

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Important Dates for Current issue

Paper Submission Open For: October 2025

Current Issue: Volume 10 | Issue 10 | October 2025

Impact Factor: 8.76

Last Date for Paper Submission: Till 31-Oct-2025

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