HPLC method development, validation, and determination of valganciclovir

HPLC method development, validation, and determination of valganciclovir

Registration ID: IJNRD_212079

Published ID: IJNRD2401105

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R.Radha , K.Kavi Priya , M.Kishore Babu , V.S.Chandrasekaran , B.Swapna,V .Anitha Kumari

valganciclovir, Antiviral, HPLC, method development, Validation

Valganciclovir is an antiviral medication used to treat cytomegalovirus (CMV) retinitis in patients diagnosed with acquired immunodeficiency syndrome (AIDS). An isocratic high performance liquid chromatography method has been developed for routine quality control of Valganciclovir. Separation was carried out by C-18, 250 x 4.6 mm, 5 um (X-Bridge, Waters) column using mobile phase Ammonium Acetate Buffer pH 3 (adjusted with glacial acetic acid) and methanol (55:45 v/v) at a flow rate of 1 ml/min. The detection was carried at 254 nm at ambient temperature. Excellent linear relationship between peak area and Valganciclovir concentration in the range of 5-30 µg/ml has been observed (r2, 0.998). Developed method has been found to be sensitive (limits of detection and quantification were 0.52µg/ml and1.58 µg/ ml, respectively), The % Assay was found to be 101.15 % ± 0.653, specific and robust (% RSD were less than 2 %, for system suitability parameters).

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"HPLC method development, validation, and determination of valganciclovir", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.9, Issue 1, page no.b28-b33, January-2024, Available :https://ijnrd.org/papers/IJNRD2401105.pdf

Volume 9 Issue 1, January-2024

Pages : b28-b33

Paper Reg. ID: IJNRD_212079

Published Paper Id: IJNRD2401105

Downloads: 000121202

Research Area: Engineering

Country: -, -, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2401105.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2401105

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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