INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016
Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI)
Valganciclovir is an antiviral medication used to treat cytomegalovirus (CMV) retinitis in patients diagnosed with acquired immunodeficiency syndrome (AIDS). An isocratic high performance liquid chromatography method has been developed for routine quality control of Valganciclovir. Separation was carried out by C-18, 250 x 4.6 mm, 5 um (X-Bridge, Waters) column using mobile phase Ammonium Acetate Buffer pH 3 (adjusted with glacial acetic acid) and methanol (55:45 v/v) at a flow rate of 1 ml/min. The detection was carried at 254 nm at ambient temperature. Excellent linear relationship between peak area and Valganciclovir concentration in the range of 5-30 µg/ml has been observed (r2, 0.998). Developed method has been found to be sensitive (limits of detection and quantification were 0.52µg/ml and1.58 µg/ ml, respectively), The % Assay was found to be 101.15 % ± 0.653, specific and robust (% RSD were less than 2 %, for system suitability parameters).
"HPLC method development, validation, and determination of valganciclovir", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.9, Issue 1, page no.b28-b33, January-2024, Available :http://www.ijnrd.org/papers/IJNRD2401105.pdf
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2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
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