INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016
Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI)
The aim of this project was to develop once daily controlled release matrix tablets of Tramadol HCl. Controlled release matrix tablets of Tramadol HCl using different polymers viz. Eudragit RS-100, Ethylcellulose, Carbopol 934Pand Polyvinyl Pyrolidone K-90 were formulated and evaluated. The tablets were prepared by wet granulation method. The tablets were evaluated for thickness, weight variation, hardness, friability, drug content and in-vitro dissolution studies. Different release models like zero order, first order, Higuchi etc were applied to in-vitro drug release data in order to evaluate the drug release mechanisms and kinetics. Three batches of matrix tablets were developed. Among these formulations, F5 formulation showed satisfactory physicochemical properties and drug content uniformity and controlled release of drug for 24 hours with maximum release of 95.73%. Matrix tablets with optimum concentration of ethyl cellulose, PVP K-90 were successfully developed and evaluated.
"FORMULATE AND EVALUATE THE TRAMADOL HYDROCHLORIDE SUSTAINED RELEASE MATRIX TABLETS USING NATURAL POLYMER (TAMARINDUS INDICA LINN. SEEDS)", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.9, Issue 1, page no.a468-a485, January-2024, Available :http://www.ijnrd.org/papers/IJNRD2401054.pdf
Downloads:
000118754
ISSN:
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Facebook Twitter Instagram LinkedIn