Paper Title
FORMULATE AND EVALUATE THE TRAMADOL HYDROCHLORIDE SUSTAINED RELEASE MATRIX TABLETS USING NATURAL POLYMER (TAMARINDUS INDICA LINN. SEEDS)
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Authors
Dr MEKALA SUNIL , CHILAKA SURESH , CHIRATHNAGANDLA HEMALATHA , SIDDA AKASH , THOKALA ADITHYA, YANAMADALA SAIPAVANI
Keywords
Matrix tablets, Eudragit RS-100, Ethylcellulose, Carbopol 934P, PVPK-90, Tramadol HCl.
Abstract
The aim of this project was to develop once daily controlled release matrix tablets of Tramadol HCl. Controlled release matrix tablets of Tramadol HCl using different polymers viz. Eudragit RS-100, Ethylcellulose, Carbopol 934Pand Polyvinyl Pyrolidone K-90 were formulated and evaluated. The tablets were prepared by wet granulation method. The tablets were evaluated for thickness, weight variation, hardness, friability, drug content and in-vitro dissolution studies. Different release models like zero order, first order, Higuchi etc were applied to in-vitro drug release data in order to evaluate the drug release mechanisms and kinetics. Three batches of matrix tablets were developed. Among these formulations, F5 formulation showed satisfactory physicochemical properties and drug content uniformity and controlled release of drug for 24 hours with maximum release of 95.73%. Matrix tablets with optimum concentration of ethyl cellulose, PVP K-90 were successfully developed and evaluated.
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How To Cite (APA)
Dr MEKALA SUNIL, CHILAKA SURESH, CHIRATHNAGANDLA HEMALATHA, SIDDA AKASH, & THOKALA ADITHYA, YANAMADALA SAIPAVANI (January-2024). FORMULATE AND EVALUATE THE TRAMADOL HYDROCHLORIDE SUSTAINED RELEASE MATRIX TABLETS USING NATURAL POLYMER (TAMARINDUS INDICA LINN. SEEDS). INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 9(1), a468-a485. https://ijnrd.org/papers/IJNRD2401054.pdf
Issue
Volume 9 Issue 1, January-2024
Pages : a468-a485
Other Publication Details
Paper Reg. ID: IJNRD_211865
Published Paper Id: IJNRD2401054
Downloads: 000121986
Research Area: Engineering
Country: -, -, India
Published Paper PDF: https://ijnrd.org/papers/IJNRD2401054.pdf
Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2401054
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Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)
ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016
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This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition
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