FORMULATE AND EVALUATE THE TRAMADOL HYDROCHLORIDE SUSTAINED RELEASE MATRIX TABLETS USING NATURAL POLYMER (TAMARINDUS INDICA LINN. SEEDS)

FORMULATE AND EVALUATE THE TRAMADOL HYDROCHLORIDE SUSTAINED RELEASE MATRIX TABLETS USING NATURAL POLYMER (TAMARINDUS INDICA LINN. SEEDS)

Registration ID: IJNRD_211865

Published ID: IJNRD2401054

DOI: Click Here to Get

Dr MEKALA SUNIL , CHILAKA SURESH , CHIRATHNAGANDLA HEMALATHA , SIDDA AKASH , THOKALA ADITHYA, YANAMADALA SAIPAVANI

Matrix tablets, Eudragit RS-100, Ethylcellulose, Carbopol 934P, PVPK-90, Tramadol HCl.

The aim of this project was to develop once daily controlled release matrix tablets of Tramadol HCl. Controlled release matrix tablets of Tramadol HCl using different polymers viz. Eudragit RS-100, Ethylcellulose, Carbopol 934Pand Polyvinyl Pyrolidone K-90 were formulated and evaluated. The tablets were prepared by wet granulation method. The tablets were evaluated for thickness, weight variation, hardness, friability, drug content and in-vitro dissolution studies. Different release models like zero order, first order, Higuchi etc were applied to in-vitro drug release data in order to evaluate the drug release mechanisms and kinetics. Three batches of matrix tablets were developed. Among these formulations, F5 formulation showed satisfactory physicochemical properties and drug content uniformity and controlled release of drug for 24 hours with maximum release of 95.73%. Matrix tablets with optimum concentration of ethyl cellulose, PVP K-90 were successfully developed and evaluated.

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"FORMULATE AND EVALUATE THE TRAMADOL HYDROCHLORIDE SUSTAINED RELEASE MATRIX TABLETS USING NATURAL POLYMER (TAMARINDUS INDICA LINN. SEEDS)", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.9, Issue 1, page no.a468-a485, January-2024, Available :https://ijnrd.org/papers/IJNRD2401054.pdf

Volume 9 Issue 1, January-2024

Pages : a468-a485

Paper Reg. ID: IJNRD_211865

Published Paper Id: IJNRD2401054

Downloads: 000121126

Research Area: Engineering

Country: -, -, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2401054.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2401054

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition

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