SYNTHESIS, CHARACTERISATION, ANTIBACTERIAL AND ANTHELMINTIC ACTIVITIES OF NOVEL BENZOTHIAZOLE DERIVATIVES

SYNTHESIS, CHARACTERISATION, ANTIBACTERIAL AND ANTHELMINTIC ACTIVITIES OF NOVEL BENZOTHIAZOLE DERIVATIVES

Registration ID: IJNRD_210312

Published ID: IJNRD2312301

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Sandhya M , Swaroopa H M , Manoj A Sharon , Nagesh T , Shahabas

Benzothiazole, Antibacterial activity, anthelmintic activity.

A design and synthesis of new Benzothiazole derivatives(3a-3h) containing thiazole moiety have been synthesized by conventional method by three step process by cyclization to form 2-amino benzothiazole, followed by Schiff’s bases mechanism and electrophilic substitution reaction with benzyl chloride. The synthesized compounds are characterized by 1H-NMR, IR and Mass spectral data. The synthesized compounds are evaluated for invitro antibacterial activity and anthelmintic activity against the antibacterial strains like gram-positive Bacillus substillus, Staphylococcus aureus gram-negative Escherichia coli, Klebsiella pneumoniae species and anthelmintic strains like Earthworms. The Streptomycin is considering as a reference standard drug for Anti- bacterial activity and Albendazole is considering as a reference standard drug for Anthelmintic activity. The compounds 3b, 3e and 3f showed good anti-bacterial activity and the compounds 3a, 3b and 3d showed good anthelmintic activity.

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"SYNTHESIS, CHARACTERISATION, ANTIBACTERIAL AND ANTHELMINTIC ACTIVITIES OF NOVEL BENZOTHIAZOLE DERIVATIVES ", IJNRD - INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT (www.IJNRD.org), ISSN:2456-4184, Vol.8, Issue 12, page no.d1-d16, December-2023, Available :https://ijnrd.org/papers/IJNRD2312301.pdf

Volume 8 Issue 12, December-2023

Pages : d1-d16

Paper Reg. ID: IJNRD_210312

Published Paper Id: IJNRD2312301

Downloads: 000121135

Research Area: Pharmacy

Country: Mandya, Karnataka , India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2312301.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2312301

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

ISSN: 2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar | ESTD YEAR: 2016

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