To evaluate Angiogenic potential of different medicinal herbs from CAM Assay

Registration ID: IJNRD_209852

Published ID: IJNRD2312218

: http://doi.one/10.1729/Journal.37161

Rafat Abdul Rauf Moosa , Bhumika Ajay Mishra , Dr. Aparna Deshmukh

angiogenesis, CAM Assay, blood vessels, dosage, Centella asiatica, Cissus quadrangularis, Madhuca longifolia, vasculature, optimization, angiogenic activity.

Angiogenesis is a complex process that involves the growth of new blood vessels from existing ones, and defects in the control of angiogenesis have been implicated in several pathological processes, including diabetic and retinopathy.[1] To investigate the potential vasculogenic activity of plants, this study evaluated the angiogenic potential of three herbaceous plants, namely: Centella asiatica, Cissus quadrangularis, and Madhuka longifolia by chick chorioallantoic membrane (CAM) assay, a high-density microvasculature extra-embryonic membrane that supports embryonic development in avian species.[2] CAM assay is a well-established tool for investigating in vivo mechanisms of angiogenesis regulation.[3] These plants have been used in various traditional medicinal practices, but their therapeutic efficacy is not fully understood. The CAM from chicken embryos was treated with various concentrations of these three herbs/plants extracted to examine their angiogenic activity.[5] The results showed that all the plant extracts have the potential to induce angiogenesis in the CAM assay. The observed angiogenic activity was measured using various parameters, including increased vascularization, higher branching complexity, and increased capillary density. The induced angiogenic activity by the plant extracts was found to be concentration-dependent and showed a dose-response relationship. The angiogenic activity of the plant extracts has significant potential for therapeutic use in promoting tissue growth and repair, as well as in the treatment of various vascular disorders.[7] A detailed understanding of the mechanism of action, optimization of dosage and suitable formulation of these herbal extracts would enable us to consider a practical option and alternative therapies in the treatment of vascular disorders.

Published Paper   E-Certificate

Rafat Abdul Rauf Moosa , Bhumika Ajay Mishra , & Dr. Aparna Deshmukh (December-2023). To evaluate Angiogenic potential of different medicinal herbs from CAM Assay. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(12), c166-c172. http://doi.one/10.1729/Journal.37161

Volume 8 Issue 12, December-2023

Pages : c166-c172

Paper Reg. ID: IJNRD_209852

Published Paper Id: IJNRD2312218

Downloads: 000122253

Research Area: Biological Science

Author Type: Indian Author

Country: mumbai , Maharashtra, India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2312218.pdf

Published Paper URL: https://ijnrd.org/viewpaperforall?paper=IJNRD2312218

Crossref DOI: http://doi.one/10.1729/Journal.37161

Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

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