Prebiotic oligosaccharides from dragon fruits Alter gut motility in mice

Registration ID: IJNRD_210185

Published ID: IJNRD2312177

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Shweta madan kachare , Shweta Shankar jadhav , Ms Komal Abhaysinh Hole

Dragon fruit, or pitaya, is used to produce the refined substance known as dragon fruit oligosaccharide (DFO). This fruit has grown in popularity all over the world and is indigenous to Central and South America. Today, it is grown all over Southeast Asia. The food Is abundant in lycopene, vitamin E, vital fatty acids, beta-carotene, and Anti-inflammatory and antioxidant properties. Both red pitaya and white-fleshed pitaya Red pitaya with red flesh (Hylocereus polyrhizus) and Hylocereus undatus Reportedly contain DFO in both its meat and peel, according to reports. In an DFO, an artificial colon, resisted hydrolysis by synthetic gastric juice.And amylase, which encouraged the growth of bifidobacteria and lactobacilli.Despit the fact that DFO’s prebiotic characteristics are abundantly obvious in vitro Study on DFO’s prebiotic effects on There is no proof in an in vivo model of the prebiotic effects of DFO on GI functions, particularly intestinal motility.

The prebiotic feature of dragon fruit oligosaccharide (DFO) enhances gut health by specifically stimulating the colonic bacteria. Intestinal motility may be impacted by altered microbial makeup. But no research has been done to Comprehend how DFO affects the motor processes of the gut. Thus, the purpose of this study In order to compare the effects of DFO and the prebiotic fructo-Probiotic bifidobacteria with oligosaccharide (FOS).The research’s mice 100, 500, and 1000 mg/kg of DFO; 1000 mg/kg of FOS; or got pure water. 1 week of daily administration of 109 CFUBifidobacterium animalis and certain therapies for 2 Weeks. Analyses of gastrointestinal transits revealed smooth motility patterns. Colons’ morphological structures and muscle (SM) contractions Wereassessed. FOS, 500, and 1000 mg/kg DFO administration significantly A higher rate of feces than the control group.In contrast to DFO groups, mice treated with FOS and bifidobacteria had shorter gut transit times and longer upper gut transit times. Temporal-spatial maps of DFO increased the number of colonic non-motility, as evidenced by colonic wall movements. Consistent with the results are propagation contractions and fecal pellet velocity.From teams that received FOS and bifidobacteria treatment. DFO likewise raised the SM contractions’ amplitude and duration. Histological marks were visible.In all groups, there were normal epithelia, crypts, goblet cells, and SM thickness. In Conclusion: Without morphological changes, DFO increased colonic SM contractions. Worked as a bulk-forming laxative that was stimulating to enhance fecal Intestinal motility and output. Consequently, DFO as a dietary supplement could Address gastrointestinal motility issues and promote gut health.

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Shweta madan kachare , Shweta Shankar jadhav , & Ms Komal Abhaysinh Hole (December-2023). Prebiotic oligosaccharides from dragon fruits Alter gut motility in mice. INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT, 8(12), b598-b619. https://ijnrd.org/papers/IJNRD2312177.pdf

Volume 8 Issue 12, December-2023

Pages : b598-b619

Paper Reg. ID: IJNRD_210185

Published Paper Id: IJNRD2312177

Downloads: 000121997

Research Area: Pharmacy

Country: Pune , Maharashtra , India

Published Paper PDF: https://ijnrd.org/papers/IJNRD2312177.pdf

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Journal Name: INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT(IJNRD)

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