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INTERNATIONAL JOURNAL OF NOVEL RESEARCH AND DEVELOPMENT International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2456-4184 | Impact factor: 8.76 | ESTD Year: 2016 Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.76 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI) |
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| Paper Title: | Novel Approaches for colon targeting drug delivery system. |
| Authors Name: | Damayanti Krishna Bokefod , Ms. Khandre Rajshree |
| Download E-Certificate: | Download |
| Author Reg. ID: |
IJNRD_210709
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| Published Paper Id: | IJNRD2312137 |
| Published In: | Volume 8 Issue 12, December-2023 |
| DOI: | |
| Abstract: | The GIT terminal part known as colon, has emerged as potential site for delivering various novel therapeutic drugs, particularly peptides. Colon targeted drug delivery system (CDDS) shows promise in treating inflammatory bowel diseases such as ulcerative colitis, Crohn’s disuse, colon cancer, and amoebiasis through both systemic and topical drug delivery. This article provides comprehensive review of colon diseases, their diagnosis, the anatomy of the colon, factors influencing drug absorption, and different approaches to colon drug delivery. It also discusses current approaches like the port system, probiotic approach, chronotropic system, colal-pred system, Enterion capsule Technology Multiarticulate system, as well as past studies on colon drug delivery, including evaluation method for site-specific drug delivery to colon. Numerous traditional methods, such as PH-dependent systems, time-controlled release systems, and microbially triggered systems, have been extensively studied for targeted drug delivery to the colon. However, these systems possess their own drawbacks, such as the inconsistent PH conditions in the colon, insufficient specificity for microbial enzymes, and limited capacity for drug loading. To overcome these limitations, novel approaches like nanotechnology-based drug delivery systems, prodrug approaches, and bioadhesive systems have been developed. |
| Keywords: | Colon drug delivery system, Gastro intestinal tract, Approaches for CDDS, |
| Cite Article: | "Novel Approaches for colon targeting drug delivery system.", International Journal of Novel Research and Development (www.ijnrd.org), ISSN:2456-4184, Vol.8, Issue 12, page no.b179-b196, December-2023, Available :http://www.ijnrd.org/papers/IJNRD2312137.pdf |
| Downloads: | 000118756 |
| ISSN: |
2456-4184 | IMPACT FACTOR: 8.76 Calculated By Google Scholar| ESTD YEAR: 2016 An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 8.76 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator |
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Published Paper ID:IJNRD2312137 Registration ID: 210709 Published In: Volume 8 Issue 12, December-2023 DOI (Digital Object Identifier): Page No: b179-b196 Country: Ahmednagar, Maharashtra , India Research Area: Pharmacy Publisher : IJ Publication Published Paper URL : https://www.ijnrd.org/viewpaperforall?paper=IJNRD2312137 Published Paper PDF: https://www.ijnrd.org/papers/IJNRD2312137 |
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ISSN: 2456-4184
Impact Factor: 8.76 and ISSN APPROVED
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